Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 78341..78966 Replicon plasmid unnamed
Accession NZ_CP026767
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C1P58_RS25010 Protein ID WP_073690939.1
Coordinates 78341..78739 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q31SG2
Locus tag C1P58_RS25015 Protein ID WP_000450530.1
Coordinates 78739..78966 (-) Length 76 a.a.

Genomic Context

C1P58_RS24985C1P58_RS24990C1P58_RS25005C1P58_RS25020C1P58_RS24995C1P58_RS25000C1P58_RS25010C1P58_RS25015
Location: 74315..75265 (951 bp)
Type: Others
Protein ID: WP_012449328.1
Location: 75330..76274 (945 bp)
Type: Others
Protein ID: WP_005027201.1
Location: 77868..78332 (465 bp)
Type: Others
Protein ID: Protein_87
Location: 79051..79467 (417 bp)
Type: Others
Protein ID: WP_171548060.1
Location: 76428..77099 (672 bp)
Type: Others
Protein ID: Protein_85
Location: 77115..77812 (698 bp)
Type: Others
Protein ID: Protein_86
Location: 78341..78739 (399 bp)
Type: Toxin
Protein ID: WP_073690939.1
Location: 78739..78966 (228 bp)
Type: Antitoxin
Protein ID: WP_000450530.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P58_RS2498574315..75265+951WP_012449328.1virulence factor VirK-
C1P58_RS2499075330..76274+945WP_005027201.1lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase-
C1P58_RS2499576428..77099-672Protein_85IS630 family transposase-
C1P58_RS2500077115..77812-698Protein_86IS1 family transposase-
C1P58_RS2500577868..78332+465Protein_87conjugal transfer protein TraD-
C1P58_RS2501078341..78739-399WP_073690939.1tRNA(fMet)-specific endonuclease VapCToxin
C1P58_RS2501578739..78966-228WP_000450530.1toxin-antitoxin system antitoxin VapBAntitoxin
C1P58_RS2502079051..79467+417WP_171548060.1conjugative relaxase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-ospI / ospI / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ipaH9.8 / ospC2 / nleE / icsP/sopA / ospB / ospC3 / ospC4 / ospD2 / ospF / ospD1 / ipgB2 / ipaH1.4 / ipaH4.5 / ipaH7.8 / ospD3/senA / ospC1 / senB / ospE2 / ospI / ospC3 / ipaJ / ipaA / ipaA / ipaA / ipaD1..209166209166
-insideIScluster/Tn-ipaH9.863036..7761814582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14846.07 Da        Isoelectric Point: 7.8605

>T95754 WP_073690939.1 NZ_CP026767:c78739-78341 [Shigella boydii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNDTREFERVGGLRTEDWS

Download         Length: 399 bp

>T95754 NZ_CP026767:c78739-78341 [Shigella boydii]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCTGCAGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAATGACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAACTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.59 Da        Isoelectric Point: 4.7513

>AT95754 WP_000450530.1 NZ_CP026767:c78966-78739 [Shigella boydii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT95754 NZ_CP026767:c78966-78739 [Shigella boydii]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBQ31SG2

References