Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 66461..66986 Replicon plasmid unnamed
Accession NZ_CP026767
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag C1P58_RS24935 Protein ID WP_073691655.1
Coordinates 66681..66986 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag C1P58_RS24930 Protein ID WP_000813626.1
Coordinates 66461..66679 (+) Length 73 a.a.

Genomic Context

C1P58_RS26325C1P58_RS24920C1P58_RS24930C1P58_RS24935C1P58_RS24940C1P58_RS24945C1P58_RS24950C1P58_RS26410C1P58_RS24965C1P58_RS26330C1P58_RS24960
Location: 62599..63154 (556 bp)
Type: Others
Protein ID: Protein_68
Location: 64608..65776 (1169 bp)
Type: Others
Protein ID: WP_134802526.1
Location: 66461..66679 (219 bp)
Type: Antitoxin
Protein ID: WP_000813626.1
Location: 66681..66986 (306 bp)
Type: Toxin
Protein ID: WP_073691655.1
Location: 67010..67117 (108 bp)
Type: Others
Protein ID: WP_023592908.1
Location: 67379..69016 (1638 bp)
Type: Others
Protein ID: WP_039076510.1
Location: 69224..69493 (270 bp)
Type: Others
Protein ID: WP_000079956.1
Location: 69490..69662 (173 bp)
Type: Others
Protein ID: Protein_77
Location: 70630..70746 (117 bp)
Type: Others
Protein ID: WP_004996477.1
Location: 64344..64553 (210 bp)
Type: Others
Protein ID: WP_073691819.1
Location: 69726..70423 (698 bp)
Type: Others
Protein ID: Protein_78
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P58_RS2632562599..63154+556Protein_68fimbria/pilus outer membrane usher protein-
C1P58_RS2633064344..64553-210WP_073691819.1hypothetical protein-
C1P58_RS2492064608..65776+1169WP_134802526.1IS3 family transposase-
C1P58_RS2493066461..66679+219WP_000813626.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
C1P58_RS2493566681..66986+306WP_073691655.1type II toxin-antitoxin system toxin CcdBToxin
C1P58_RS2494067010..67117+108WP_023592908.1transposase domain-containing protein-
C1P58_RS2494567379..69016+1638WP_039076510.1T3SS effector E3 ubiquitin-protein ligase IpaH9.8-
C1P58_RS2495069224..69493+270WP_000079956.1hypothetical protein-
C1P58_RS2641069490..69662+173Protein_77type II toxin-antitoxin system RelE/ParE family toxin-
C1P58_RS2496069726..70423-698Protein_78IS1 family transposase-
C1P58_RS2496570630..70746+117WP_004996477.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-ospI / ospI / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ipaH9.8 / ospC2 / nleE / icsP/sopA / ospB / ospC3 / ospC4 / ospD2 / ospF / ospD1 / ipgB2 / ipaH1.4 / ipaH4.5 / ipaH7.8 / ospD3/senA / ospC1 / senB / ospE2 / ospI / ospC3 / ipaJ / ipaA / ipaA / ipaA / ipaD1..209166209166
-insideIScluster/Tn-ipaH9.863036..7761814582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11722.56 Da        Isoelectric Point: 6.4674

>T95753 WP_073691655.1 NZ_CP026767:66681-66986 [Shigella boydii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T95753 NZ_CP026767:66681-66986 [Shigella boydii]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGGTCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT95753 WP_000813626.1 NZ_CP026767:66461-66679 [Shigella boydii]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT95753 NZ_CP026767:66461-66679 [Shigella boydii]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7BEK0

References