95741

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3613083..3613701 Replicon chromosome
Accession NZ_CP026766
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C1P58_RS18625 Protein ID WP_001291435.1
Coordinates 3613083..3613301 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q325D5
Locus tag C1P58_RS18630 Protein ID WP_000344809.1
Coordinates 3613327..3613701 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P58_RS18595 3609541..3610192 - 652 Protein_3526 transposase -
C1P58_RS18600 3610507..3610650 - 144 Protein_3527 hypothetical protein -
C1P58_RS18605 3610706..3611862 + 1157 WP_129592860.1 IS3 family transposase -
C1P58_RS18615 3611906..3612244 - 339 Protein_3529 hypothetical protein -
C1P58_RS18620 3612360..3612911 - 552 WP_000102569.1 maltose O-acetyltransferase -
C1P58_RS18625 3613083..3613301 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
C1P58_RS18630 3613327..3613701 - 375 WP_000344809.1 Hha toxicity modulator TomB Antitoxin
C1P58_RS18635 3614247..3617396 - 3150 WP_073690761.1 efflux RND transporter permease AcrB -
C1P58_RS18640 3617419..3618612 - 1194 WP_073690760.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T95741 WP_001291435.1 NZ_CP026766:c3613301-3613083 [Shigella boydii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T95741 NZ_CP026766:c3613301-3613083 [Shigella boydii]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14583.42 Da        Isoelectric Point: 4.5934

>AT95741 WP_000344809.1 NZ_CP026766:c3613701-3613327 [Shigella boydii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNYGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT95741 NZ_CP026766:c3613701-3613327 [Shigella boydii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATTATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB Q325D5

References