95739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2168926..2169557 Replicon chromosome
Accession NZ_CP026766
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P58_RS11340 Protein ID WP_001259385.1
Coordinates 2169282..2169557 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag C1P58_RS11335 Protein ID WP_000593554.1
Coordinates 2168926..2169285 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P58_RS11310 2165058..2166002 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
C1P58_RS11315 2165999..2166832 + 834 WP_001008950.1 nickel ABC transporter permease subunit NikC -
C1P58_RS11320 2166832..2167596 + 765 WP_001136224.1 nickel import ATP-binding protein NikD -
C1P58_RS11325 2167593..2168399 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
C1P58_RS11330 2168405..2168806 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
C1P58_RS11335 2168926..2169285 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C1P58_RS11340 2169282..2169557 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
C1P58_RS11345 2169630..2170754 - 1125 WP_001216257.1 ABC transporter permease -
C1P58_RS11350 2170754..2173489 - 2736 WP_000149138.1 ribosome-associated ATPase/putative transporter RbbA -
C1P58_RS11355 2173486..2174553 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T95739 WP_001259385.1 NZ_CP026766:c2169557-2169282 [Shigella boydii]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T95739 NZ_CP026766:c2169557-2169282 [Shigella boydii]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT95739 WP_000593554.1 NZ_CP026766:c2169285-2168926 [Shigella boydii]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT95739 NZ_CP026766:c2169285-2168926 [Shigella boydii]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References