Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2168926..2169557 Replicon chromosome
Accession NZ_CP026766
Organism Shigella boydii strain 59-248

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag C1P58_RS11340 Protein ID WP_001259385.1
Coordinates 2169282..2169557 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag C1P58_RS11335 Protein ID WP_000593554.1
Coordinates 2168926..2169285 (-) Length 120 a.a.

Genomic Context

C1P58_RS11310C1P58_RS11315C1P58_RS11320C1P58_RS11325C1P58_RS11330C1P58_RS11335C1P58_RS11340C1P58_RS11345C1P58_RS11350C1P58_RS11355
Location: 2165058..2166002 (945 bp)
Type: Others
Protein ID: WP_000947068.1
Location: 2165999..2166832 (834 bp)
Type: Others
Protein ID: WP_001008950.1
Location: 2166832..2167596 (765 bp)
Type: Others
Protein ID: WP_001136224.1
Location: 2167593..2168399 (807 bp)
Type: Others
Protein ID: WP_000173706.1
Location: 2168405..2168806 (402 bp)
Type: Others
Protein ID: WP_001190062.1
Location: 2168926..2169285 (360 bp)
Type: Antitoxin
Protein ID: WP_000593554.1
Location: 2169282..2169557 (276 bp)
Type: Toxin
Protein ID: WP_001259385.1
Location: 2169630..2170754 (1125 bp)
Type: Others
Protein ID: WP_001216257.1
Location: 2170754..2173489 (2736 bp)
Type: Others
Protein ID: WP_000149138.1
Location: 2173486..2174553 (1068 bp)
Type: Others
Protein ID: WP_000361467.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P58_RS113102165058..2166002+945WP_000947068.1nickel ABC transporter permease subunit NikB-
C1P58_RS113152165999..2166832+834WP_001008950.1nickel ABC transporter permease subunit NikC-
C1P58_RS113202166832..2167596+765WP_001136224.1nickel import ATP-binding protein NikD-
C1P58_RS113252167593..2168399+807WP_000173706.1nickel import ATP-binding protein NikE-
C1P58_RS113302168405..2168806+402WP_001190062.1nickel-responsive transcriptional regulator NikR-
C1P58_RS113352168926..2169285-360WP_000593554.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
C1P58_RS113402169282..2169557-276WP_001259385.1type II toxin-antitoxin system HicA family toxinToxin
C1P58_RS113452169630..2170754-1125WP_001216257.1ABC transporter permease-
C1P58_RS113502170754..2173489-2736WP_000149138.1ribosome-associated ATPase/putative transporter RbbA-
C1P58_RS113552173486..2174553-1068WP_000361467.1HlyD family secretion protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T95739 WP_001259385.1 NZ_CP026766:c2169557-2169282 [Shigella boydii]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T95739 NZ_CP026766:c2169557-2169282 [Shigella boydii]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT95739 WP_000593554.1 NZ_CP026766:c2169285-2168926 [Shigella boydii]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT95739 NZ_CP026766:c2169285-2168926 [Shigella boydii]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7TTW8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H2GM94

References