Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 96284..97041 Replicon plasmid unnamed
Accession NZ_CP026763
Organism Shigella boydii strain NCTC 9850

Toxin (Protein)


Gene name tacT Uniprot ID Q31SN7
Locus tag C1P50_RS24845 Protein ID WP_000501969.1
Coordinates 96556..97041 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q31SN8
Locus tag C1P50_RS24840 Protein ID WP_011114751.1
Coordinates 96284..96568 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P50_RS24795 91518..92746 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
C1P50_RS24805 92994..93120 + 127 Protein_107 IS110 family transposase -
C1P50_RS24810 93130..93729 - 600 Protein_108 IS3 family transposase -
C1P50_RS24815 93786..94999 + 1214 WP_164997312.1 IS3 family transposase -
C1P50_RS24825 95043..95611 - 569 Protein_110 transposase -
C1P50_RS24840 96284..96568 + 285 WP_011114751.1 DUF1778 domain-containing protein Antitoxin
C1P50_RS24845 96556..97041 + 486 WP_000501969.1 GNAT family N-acetyltransferase Toxin
C1P50_RS24850 97082..97870 - 789 Protein_113 IS66 family transposase -
C1P50_RS24860 99161..99340 + 180 Protein_115 transposase -
C1P50_RS24870 99866..101044 + 1179 WP_073714961.1 group II intron reverse transcriptase/maturase -
C1P50_RS24875 101127..101306 + 180 Protein_117 transposase domain-containing protein -
C1P50_RS24880 101336..101818 - 483 Protein_118 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospG / ipaH9.8 / ospC3 / ipaH4.5 / ipaH7.8 / senB / ospC1 / ospD3/senA / ospE2 / ipaH1.4 / ospI / ipgB2 / ospD1 / ospF / ospD2 / ospC4 / ospB / icsP/sopA / nleE / ospC2 1..150497 150497
- inside IScluster/Tn - ospC1 / ospD3/senA / ospE2 / ipaH1.4 / ospI 62198..99112 36914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-151)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17712.54 Da        Isoelectric Point: 10.1083

>T95712 WP_000501969.1 NZ_CP026763:96556-97041 [Shigella boydii]
MGCVTAPEPLSSFHQVAEFVSGEAVLDDWLKQKGLKNQAIGATRTFVVCRKGTQQIVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTENAKQFYIHHGFKPSKTQVQTLFLKLP
Q

Download         Length: 486 bp

>T95712 NZ_CP026763:96556-97041 [Shigella boydii]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10871.52 Da        Isoelectric Point: 4.6812

>AT95712 WP_011114751.1 NZ_CP026763:96284-96568 [Shigella boydii]
MIYGGFMKSGVQLNLRARESQRILIDAAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADDP
AIEKLLARKPQWDV

Download         Length: 285 bp

>AT95712 NZ_CP026763:96284-96568 [Shigella boydii]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31SN7

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CUJ1

References