Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB-PIN |
| Location | 2878899..2879523 | Replicon | chromosome |
| Accession | NC_002754 | ||
| Organism | Sulfolobus solfataricus P2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97U93 |
| Locus tag | SSO_RS15165 | Protein ID | WP_009989951.1 |
| Coordinates | 2878899..2879300 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q97U92 |
| Locus tag | SSO_RS15170 | Protein ID | WP_009989953.1 |
| Coordinates | 2879278..2879523 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSO_RS15150 (SSO3124) | 2874196..2875317 | - | 1122 | WP_009989946.1 | arabinonate dehydratase | - |
| SSO_RS15155 (SSO3125) | 2875411..2876634 | + | 1224 | WP_009989947.1 | HD domain-containing protein | - |
| SSO_RS15160 (SSO3127) | 2876706..2878655 | - | 1950 | WP_009989948.1 | Sip1-related alpha-galactosidase | - |
| SSO_RS15165 (SSO3128) | 2878899..2879300 | - | 402 | WP_009989951.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SSO_RS15170 (SSO12018) | 2879278..2879523 | - | 246 | WP_009989953.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| SSO_RS15175 (SSO3129) | 2879784..2881247 | + | 1464 | WP_009989954.1 | MFS transporter | - |
| SSO_RS15180 (SSO3130) | 2881292..2882443 | - | 1152 | WP_009989955.1 | lactate utilization protein B | - |
| SSO_RS15185 (SSO3131) | 2882436..2883335 | - | 900 | WP_009989956.1 | heterodisulfide reductase-related iron-sulfur binding cluster | - |
| SSO_RS15190 (SSO3132) | 2883400..2884029 | + | 630 | WP_009989958.1 | MBL fold metallo-hydrolase | - |
| SSO_RS15195 | 2884031..2884249 | - | 219 | WP_009989960.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 15187.83 Da Isoelectric Point: 9.5710
>T957 WP_009989951.1 NC_002754:c2879300-2878899 [Saccharolobus solfataricus P2]
MRKKYVLDAGPLSLLFAGRKEIKKYFEEIYTGDAIIYMSEVNLAELLYIYILKKGKDVAIARHRYIRNSPIKVISPNERI
TENAALLKSKYSYLSLADAFLIATAKEVKGKVITTDEDIEKTKEVETIKIPLD
MRKKYVLDAGPLSLLFAGRKEIKKYFEEIYTGDAIIYMSEVNLAELLYIYILKKGKDVAIARHRYIRNSPIKVISPNERI
TENAALLKSKYSYLSLADAFLIATAKEVKGKVITTDEDIEKTKEVETIKIPLD
Download Length: 402 bp
>T957 NC_002754:c2879300-2878899 [Saccharolobus solfataricus P2]
TTGAGAAAGAAATACGTTCTTGATGCAGGACCTTTATCTTTATTATTTGCCGGAAGAAAAGAAATTAAAAAGTATTTTGA
AGAAATTTATACAGGCGATGCGATAATTTATATGAGTGAGGTAAATTTAGCTGAACTCCTCTATATTTATATTTTAAAGA
AGGGGAAAGATGTTGCGATAGCTAGGCATAGATATATTAGAAATTCTCCAATTAAAGTAATATCTCCTAATGAAAGAATA
ACTGAAAATGCCGCTTTATTGAAGAGTAAATATTCTTATCTATCACTAGCTGATGCGTTTTTAATAGCTACAGCAAAGGA
AGTCAAAGGGAAAGTTATCACAACTGACGAAGACATAGAAAAGACTAAAGAAGTTGAAACAATAAAAATTCCTTTAGATT
AA
TTGAGAAAGAAATACGTTCTTGATGCAGGACCTTTATCTTTATTATTTGCCGGAAGAAAAGAAATTAAAAAGTATTTTGA
AGAAATTTATACAGGCGATGCGATAATTTATATGAGTGAGGTAAATTTAGCTGAACTCCTCTATATTTATATTTTAAAGA
AGGGGAAAGATGTTGCGATAGCTAGGCATAGATATATTAGAAATTCTCCAATTAAAGTAATATCTCCTAATGAAAGAATA
ACTGAAAATGCCGCTTTATTGAAGAGTAAATATTCTTATCTATCACTAGCTGATGCGTTTTTAATAGCTACAGCAAAGGA
AGTCAAAGGGAAAGTTATCACAACTGACGAAGACATAGAAAAGACTAAAGAAGTTGAAACAATAAAAATTCCTTTAGATT
AA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9426.16 Da Isoelectric Point: 8.5303
>AT957 WP_009989953.1 NC_002754:c2879523-2879278 [Saccharolobus solfataricus P2]
MERRRVKVYKKGIIVIPKEIREKLGIKEGDIIELIVNGDRISIEKPLTLLDLFGIDGDEALEIAKEIIKERRKEVEKEIR
S
MERRRVKVYKKGIIVIPKEIREKLGIKEGDIIELIVNGDRISIEKPLTLLDLFGIDGDEALEIAKEIIKERRKEVEKEIR
S
Download Length: 246 bp
>AT957 NC_002754:c2879523-2879278 [Saccharolobus solfataricus P2]
ATGGAAAGACGTAGAGTAAAGGTTTATAAAAAAGGAATAATAGTTATTCCTAAAGAAATAAGGGAAAAGCTTGGAATAAA
AGAGGGAGATATAATAGAATTAATTGTTAATGGAGATAGGATAAGCATAGAGAAACCTTTGACGCTTTTGGATCTTTTTG
GAATAGACGGAGACGAGGCTTTAGAAATTGCTAAGGAAATAATTAAGGAAAGGAGGAAAGAAGTTGAGAAAGAAATACGT
TCTTGA
ATGGAAAGACGTAGAGTAAAGGTTTATAAAAAAGGAATAATAGTTATTCCTAAAGAAATAAGGGAAAAGCTTGGAATAAA
AGAGGGAGATATAATAGAATTAATTGTTAATGGAGATAGGATAAGCATAGAGAAACCTTTGACGCTTTTGGATCTTTTTG
GAATAGACGGAGACGAGGCTTTAGAAATTGCTAAGGAAATAATTAAGGAAAGGAGGAAAGAAGTTGAGAAAGAAATACGT
TCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3K075 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MD22 |
References
(1) Charlotte R Cooper et al. (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society Transactions 37(Pt 1):123-6. [PubMed:19143615]
(2) Sabrina Tachdjian et al. (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of Bacteriology 188(12):4553-9. [PubMed:16740961]