Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2062844..2063526 Replicon chromosome
Accession NZ_CP026761
Organism Acinetobacter baumannii strain AR_0078

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AM457_RS09755 Protein ID WP_002077557.1
Coordinates 2062844..2063026 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM457_RS09760 Protein ID WP_000966687.1
Coordinates 2063122..2063526 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM457_RS09715 2058389..2058757 + 369 WP_000539744.1 hypothetical protein -
AM457_RS09720 2058714..2059157 + 444 WP_002039534.1 hypothetical protein -
AM457_RS09725 2059159..2059377 + 219 WP_001277691.1 hypothetical protein -
AM457_RS09730 2059474..2059824 + 351 WP_000064573.1 hypothetical protein -
AM457_RS09735 2059824..2060921 + 1098 WP_001284998.1 hypothetical protein -
AM457_RS09740 2061016..2061933 + 918 WP_000094281.1 hypothetical protein -
AM457_RS09745 2062003..2062518 + 516 WP_001185611.1 hypothetical protein -
AM457_RS09755 2062844..2063026 + 183 WP_002077557.1 type II toxin-antitoxin system HicA family toxin Toxin
AM457_RS09760 2063122..2063526 + 405 WP_000966687.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM457_RS09765 2063767..2064600 + 834 WP_000658554.1 hypothetical protein -
AM457_RS09770 2064615..2065025 + 411 WP_000064169.1 hypothetical protein -
AM457_RS09775 2065182..2065358 + 177 WP_001983384.1 hypothetical protein -
AM457_RS09780 2065367..2065690 + 324 WP_000523925.1 DUF4236 domain-containing protein -
AM457_RS09785 2065722..2066405 + 684 WP_005123868.1 hypothetical protein -
AM457_RS09790 2066477..2066803 + 327 WP_000721695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2033084..2082396 49312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6709.86 Da        Isoelectric Point: 10.5523

>T95692 WP_002077557.1 NZ_CP026761:2062844-2063026 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T95692 NZ_CP026761:2062844-2063026 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTACGAGGTTAGGGTTACAGGAAGTCATCATCACTT
CAAGCACCCAACCAAAAAGGGGTTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14664.59 Da        Isoelectric Point: 4.3543

>AT95692 WP_000966687.1 NZ_CP026761:2063122-2063526 [Acinetobacter baumannii]
MLYPIAIERGSDNEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPEASDLSTYIDDPAYKGMIWAV
TEIDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT95692 NZ_CP026761:2063122-2063526 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGGGGATCAGATAACGAGGCATTTGGTGTCACAGTTCCTGATATACCTGGTTGTTT
TAGTGCGGGTGATACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGTCATTTAGAAATTCTGGCTGAAG
ATGGTGAAGAAATTCCTGAAGCATCCGATTTAAGTACATATATCGATGATCCAGCCTATAAAGGAATGATTTGGGCTGTT
ACCGAGATCGATGTAAGTCGTTATCTCGGTAAACCAGAAAAAATAAATGTGACTTTACCCAGCAGATTAATCCGGAAAAT
TGATGATAATGTAGGTAAAGATAAAAGATTTAAAACCCGTTCAGCTTTTTTAGCAGCTGGTGCAGAGAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References