Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 449816..450469 Replicon chromosome
Accession NZ_CP026761
Organism Acinetobacter baumannii strain AR_0078

Toxin (Protein)


Gene name cptA Uniprot ID A0A009I802
Locus tag AM457_RS02030 Protein ID WP_000607076.1
Coordinates 449816..450205 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AM457_RS02035 Protein ID WP_001288210.1
Coordinates 450212..450469 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM457_RS02015 444933..447128 - 2196 WP_001158911.1 TRAP transporter large permease subunit -
AM457_RS02020 447316..447882 - 567 WP_000651536.1 rhombosortase -
AM457_RS02025 447960..449045 - 1086 WP_000049106.1 hypothetical protein -
AM457_RS02030 449816..450205 - 390 WP_000607076.1 hypothetical protein Toxin
AM457_RS02035 450212..450469 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AM457_RS02040 450657..451829 + 1173 WP_001190555.1 acyl-CoA dehydrogenase family protein -
AM457_RS02045 451878..453368 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
AM457_RS02050 453550..453927 - 378 WP_001216380.1 50S ribosomal protein L17 -
AM457_RS02055 453946..454953 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15598.85 Da        Isoelectric Point: 10.3889

>T95691 WP_000607076.1 NZ_CP026761:c450205-449816 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGNKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T95691 NZ_CP026761:c450205-449816 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGCCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTAATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT95691 WP_001288210.1 NZ_CP026761:c450469-450212 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT95691 NZ_CP026761:c450469-450212 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009I802

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References