Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4951463..4952082 Replicon chromosome
Accession NZ_CP026756
Organism Klebsiella aerogenes strain AR_0062

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag AM441_RS24365 Protein ID WP_015367918.1
Coordinates 4951864..4952082 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag AM441_RS24360 Protein ID WP_015367917.1
Coordinates 4951463..4951837 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM441_RS24350 4946622..4947821 + 1200 WP_104891155.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AM441_RS24355 4947844..4950990 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
AM441_RS24360 4951463..4951837 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
AM441_RS24365 4951864..4952082 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
AM441_RS24370 4952214..4952777 + 564 WP_015367919.1 maltose O-acetyltransferase -
AM441_RS24380 4952903..4953367 + 465 WP_015367920.1 YlaC family protein -
AM441_RS24385 4953342..4954796 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
AM441_RS24390 4954899..4955609 + 711 WP_015367922.1 GNAT family N-acetyltransferase -
AM441_RS24395 4955606..4955746 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AM441_RS24400 4955749..4956009 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T95689 WP_015367918.1 NZ_CP026756:4951864-4952082 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T95689 NZ_CP026756:4951864-4952082 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT95689 WP_015367917.1 NZ_CP026756:4951463-4951837 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT95689 NZ_CP026756:4951463-4951837 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References