Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3628540..3629279 Replicon chromosome
Accession NZ_CP026756
Organism Klebsiella aerogenes strain AR_0062

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag AM441_RS17745 Protein ID WP_032705770.1
Coordinates 3628794..3629279 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag AM441_RS17740 Protein ID WP_015366659.1
Coordinates 3628540..3628806 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM441_RS17720 3624833..3625450 + 618 WP_032705773.1 response regulator transcription factor -
AM441_RS17725 3625546..3626043 + 498 WP_015366656.1 heme-binding protein -
AM441_RS17730 3626444..3626977 + 534 WP_100280375.1 N-acetyltransferase -
AM441_RS17735 3627032..3628267 - 1236 WP_015366658.1 MFS transporter -
AM441_RS17740 3628540..3628806 + 267 WP_015366659.1 DUF1778 domain-containing protein Antitoxin
AM441_RS17745 3628794..3629279 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
AM441_RS17750 3629351..3630967 + 1617 WP_015366662.1 FAD-NAD(P)-binding protein -
AM441_RS17755 3631086..3632186 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
AM441_RS17760 3632243..3632401 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
AM441_RS17765 3632662..3633732 + 1071 WP_015366664.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T95688 WP_032705770.1 NZ_CP026756:3628794-3629279 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T95688 NZ_CP026756:3628794-3629279 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCACAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACTCGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT95688 WP_015366659.1 NZ_CP026756:3628540-3628806 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT95688 NZ_CP026756:3628540-3628806 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCTTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACTCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References