Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2091443..2092223 Replicon chromosome
Accession NZ_CP026756
Organism Klebsiella aerogenes strain AR_0062

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag AM441_RS10340 Protein ID WP_015370123.1
Coordinates 2091443..2091772 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AM441_RS10345 Protein ID WP_127175768.1
Coordinates 2091825..2092223 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM441_RS27195 2086809..2086961 - 153 WP_157844032.1 hypothetical protein -
AM441_RS10310 2087252..2087479 + 228 WP_071647620.1 DUF1272 domain-containing protein -
AM441_RS10315 2087807..2088625 + 819 WP_032706441.1 AraC family transcriptional regulator -
AM441_RS10320 2088701..2089063 + 363 WP_015370120.1 cupin domain-containing protein -
AM441_RS10325 2089263..2089799 + 537 WP_015370121.1 dihydrofolate reductase family protein -
AM441_RS10330 2089975..2090775 + 801 WP_015370122.1 nucleotidyltransferase domain-containing protein -
AM441_RS10335 2090934..2091035 - 102 Protein_1916 preprotein translocase -
AM441_RS10340 2091443..2091772 - 330 WP_015370123.1 TA system toxin CbtA family protein Toxin
AM441_RS10345 2091825..2092223 - 399 WP_127175768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM441_RS10350 2092192..2092413 - 222 WP_015370125.1 DUF987 domain-containing protein -
AM441_RS10355 2092434..2092913 - 480 WP_049045114.1 DNA repair protein RadC -
AM441_RS10360 2092925..2093404 - 480 WP_049045115.1 antirestriction protein -
AM441_RS10370 2093674..2094492 - 819 WP_015370128.1 DUF945 domain-containing protein -
AM441_RS10375 2094590..2094823 - 234 WP_015370129.1 DUF905 domain-containing protein -
AM441_RS10380 2094917..2095753 - 837 WP_015370130.1 hypothetical protein -
AM441_RS10385 2095811..2096056 - 246 WP_032710460.1 hypothetical protein -
AM441_RS10390 2096056..2096283 - 228 WP_049045116.1 hypothetical protein -
AM441_RS10395 2096356..2096763 - 408 WP_032710459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2088701..2118377 29676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(33-131)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12493.28 Da        Isoelectric Point: 7.3984

>T95679 WP_015370123.1 NZ_CP026756:c2091772-2091443 [Klebsiella aerogenes]
MQTLSLHPTRATQPYLSPVETWQRLLTHLLSEHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

>T95679 NZ_CP026756:c2091772-2091443 [Klebsiella aerogenes]
ATGCAAACCTTATCATTACACCCGACAAGGGCGACTCAGCCCTATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTTTTATCGGAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14730.76 Da        Isoelectric Point: 7.0372

>AT95679 WP_127175768.1 NZ_CP026756:c2092223-2091825 [Klebsiella aerogenes]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKTTVTPYFGARLVQEGNRLHYLADRASITGTFSDADLRHLDQA
FPVLLKQLELMLVSGELTSRHQHRITLYHNGLTCEADTLGSCGYVYIAIYPD

Download         Length: 399 bp

>AT95679 NZ_CP026756:c2092223-2091825 [Klebsiella aerogenes]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATTGCCGAACCCTGGTGGGGACTCAAAACCACCGTCACGCCGTACTTTGGCGCACGACTGGTGCAGGAAGGCA
ACCGGCTGCATTACCTGGCTGATCGTGCCAGTATCACCGGGACATTCAGCGACGCGGATTTACGCCATCTCGACCAGGCG
TTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACCTCCCGCCATCAGCACCGCATCACGCT
ATATCACAATGGACTGACTTGCGAAGCCGATACACTCGGCTCTTGTGGTTACGTCTACATCGCTATTTATCCCGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References