Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1767782..1768439 Replicon chromosome
Accession NZ_CP026756
Organism Klebsiella aerogenes strain AR_0062

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag AM441_RS08705 Protein ID WP_015369792.1
Coordinates 1768029..1768439 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag AM441_RS08700 Protein ID WP_015369791.1
Coordinates 1767782..1768048 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM441_RS08675 1763009..1764442 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
AM441_RS08680 1764562..1765290 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
AM441_RS08685 1765341..1765652 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
AM441_RS08690 1765817..1766476 + 660 WP_008806429.1 hemolysin III family protein -
AM441_RS08695 1766575..1767558 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
AM441_RS08700 1767782..1768048 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
AM441_RS08705 1768029..1768439 + 411 WP_015369792.1 protein YgfX Toxin
AM441_RS08710 1768447..1768968 - 522 WP_015369793.1 flavodoxin FldB -
AM441_RS08715 1769069..1769965 + 897 WP_015369794.1 site-specific tyrosine recombinase XerD -
AM441_RS08720 1769988..1770701 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM441_RS08725 1770707..1772440 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T95678 WP_015369792.1 NZ_CP026756:1768029-1768439 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T95678 NZ_CP026756:1768029-1768439 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTAATCGACTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAGCCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT95678 WP_015369791.1 NZ_CP026756:1767782-1768048 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95678 NZ_CP026756:1767782-1768048 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGATAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References