Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 12572..13097 Replicon plasmid tig00000042_pilon
Accession NZ_CP026754
Organism Escherichia coli strain AR_0077

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag AM456_RS00130 Protein ID WP_042191934.1
Coordinates 12572..12877 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag AM456_RS00135 Protein ID WP_085460092.1
Coordinates 12879..13097 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM456_RS26265 8598..8972 - 375 WP_000752649.1 hypothetical protein -
AM456_RS00110 8972..9604 - 633 WP_000312330.1 ParA family protein -
AM456_RS00120 10452..11207 - 756 WP_000807692.1 replication initiation protein RepE -
AM456_RS00125 11765..12571 - 807 WP_104888851.1 site-specific integrase -
AM456_RS00130 12572..12877 - 306 WP_042191934.1 type II toxin-antitoxin system toxin CcdB Toxin
AM456_RS00135 12879..13097 - 219 WP_085460092.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
AM456_RS00140 13694..13963 + 270 WP_097411212.1 hypothetical protein -
AM456_RS00145 13951..14547 + 597 WP_104888852.1 hypothetical protein -
AM456_RS00155 14841..15632 + 792 WP_172943697.1 polysaccharide deacetylase family protein -
AM456_RS00160 15635..16723 + 1089 WP_097411209.1 putative hexosyltransferase CapU -
AM456_RS00165 16728..17678 + 951 WP_097411208.1 virulence factor VirK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeI / faeH / faeF / faeE / faeD / faeC 1..90045 90045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11682.45 Da        Isoelectric Point: 6.4674

>T95637 WP_042191934.1 NZ_CP026754:c12877-12572 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTSGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T95637 NZ_CP026754:c12877-12572 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GTCCGGGCGACGGATGGTGATCCCCCTGGCCAGCGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCCGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8400.36 Da        Isoelectric Point: 4.7405

>AT95637 WP_085460092.1 NZ_CP026754:c13097-12879 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQAENREGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT95637 NZ_CP026754:c13097-12879 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGTGCTGAACGCTGGCAGGCTGAAAATCGGGAAGGGATGGCAG
AGGTCGCCAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References