Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1017343..1017994 Replicon chromosome
Accession NZ_CP026750
Organism Acinetobacter baumannii strain WCHAB005133

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag C5B74_RS05230 Protein ID WP_000838146.1
Coordinates 1017343..1017525 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag C5B74_RS05235 Protein ID WP_000966689.1
Coordinates 1017590..1017994 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B74_RS05185 1012600..1013265 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
C5B74_RS05190 1013270..1013659 + 390 WP_000008492.1 hypothetical protein -
C5B74_RS05195 1013616..1014029 + 414 WP_001197735.1 hypothetical protein -
C5B74_RS05200 1014038..1014442 + 405 WP_000248324.1 hypothetical protein -
C5B74_RS05205 1014414..1014782 + 369 WP_000539752.1 hypothetical protein -
C5B74_RS05210 1014784..1015182 + 399 WP_001132270.1 hypothetical protein -
C5B74_RS05215 1015184..1015396 + 213 WP_000121166.1 hypothetical protein -
C5B74_RS05220 1015504..1016433 + 930 WP_000094300.1 hypothetical protein -
C5B74_RS05225 1016478..1017011 + 534 WP_001185622.1 hypothetical protein -
C5B74_RS05230 1017343..1017525 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
C5B74_RS05235 1017590..1017994 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C5B74_RS05240 1018075..1018476 + 402 WP_000720591.1 hypothetical protein -
C5B74_RS05245 1018537..1022502 + 3966 WP_000191304.1 tape measure protein -
C5B74_RS05250 1022620..1022961 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 986950..1041565 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T95617 WP_000838146.1 NZ_CP026750:1017343-1017525 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T95617 NZ_CP026750:1017343-1017525 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT95617 WP_000966689.1 NZ_CP026750:1017590-1017994 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT95617 NZ_CP026750:1017590-1017994 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References