Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 38940..39564 | Replicon | plasmid pOXA58_005133 |
Accession | NZ_CP026749 | ||
Organism | Acinetobacter baumannii strain WCHAB005133 |
Toxin (Protein)
Gene name | relE | Uniprot ID | N9CKJ9 |
Locus tag | C5B74_RS00280 | Protein ID | WP_004647749.1 |
Coordinates | 38940..39236 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | C5B74_RS00285 | Protein ID | WP_104915067.1 |
Coordinates | 39238..39564 (+) | Length | 109 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C5B74_RS00245 | 35667..35912 | + | 246 | WP_026438268.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
C5B74_RS00250 | 35902..36195 | + | 294 | WP_004733298.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
C5B74_RS00255 | 36261..36575 | - | 315 | WP_005108843.1 | hypothetical protein | - |
C5B74_RS00260 | 36682..37113 | + | 432 | WP_104915069.1 | hypothetical protein | - |
C5B74_RS00265 | 37103..37429 | + | 327 | WP_019838418.1 | hypothetical protein | - |
C5B74_RS00275 | 37480..38699 | + | 1220 | WP_104915068.1 | IS3 family transposase | - |
C5B74_RS00280 | 38940..39236 | + | 297 | WP_004647749.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C5B74_RS00285 | 39238..39564 | + | 327 | WP_104915067.1 | putative addiction module antidote protein | Antitoxin |
C5B74_RS00290 | 39617..39820 | - | 204 | WP_004896916.1 | hypothetical protein | - |
C5B74_RS00300 | 40200..40511 | + | 312 | WP_104915071.1 | BrnT family toxin | - |
C5B74_RS00305 | 40474..40788 | + | 315 | WP_019838467.1 | BrnA antitoxin family protein | - |
C5B74_RS00310 | 40857..41360 | - | 504 | WP_104915066.1 | hypothetical protein | - |
C5B74_RS00315 | 41566..41922 | + | 357 | Protein_50 | type II toxin-antitoxin system RelE/ParE family toxin | - |
C5B74_RS00320 | 41915..42043 | + | 129 | Protein_51 | transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | blaOXA-58 / floR / sul2 | - | 1..42455 | 42455 | |
- | inside | IScluster/Tn | - | - | 37480..42454 | 4974 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11584.25 Da Isoelectric Point: 5.8801
>T95615 WP_004647749.1 NZ_CP026749:38940-39236 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED
Download Length: 297 bp
>T95615 NZ_CP026749:38940-39236 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTGCCAGAATTTGATGAATGGTTAGATGGCATTAAAGACAATATGACCCGTATTCGCCTAAA
TCGTAGACTAGATAAGGTTCAACGTGGAAATTGGGGAGACATTAAGCCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAGCATGGTGACGTAGTGATTGTAATGCTTGGAGGCGGAGATAAATCG
ACTCAACAACAAGACATTGATCGTGCAGTCAAACTATCGAAAACATTGGAGGATTAA
ATGATTGAAATTAAACGTCTGCCAGAATTTGATGAATGGTTAGATGGCATTAAAGACAATATGACCCGTATTCGCCTAAA
TCGTAGACTAGATAAGGTTCAACGTGGAAATTGGGGAGACATTAAGCCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAGCATGGTGACGTAGTGATTGTAATGCTTGGAGGCGGAGATAAATCG
ACTCAACAACAAGACATTGATCGTGCAGTCAAACTATCGAAAACATTGGAGGATTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11901.74 Da Isoelectric Point: 7.2020
>AT95615 WP_104915067.1 NZ_CP026749:39238-39564 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNIVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHAQNFKKYSKNGSL
MVKVADLPSFDMAESLKTEEDIVMYLNIVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHAQNFKKYSKNGSL
Download Length: 327 bp
>AT95615 NZ_CP026749:39238-39564 [Acinetobacter baumannii]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
CATAGTTCTTGAAGAAAATGATCCAGCTGAATTAGCTCATGCCCTTGGCGTAATTGCCAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGACGTGAAGCACTTTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCATTAGGCTTAAAACTCACTGTACAACACGCCCAAAACTTTAAAAAATATAGTAAAAATGGGAG
CTTATAG
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
CATAGTTCTTGAAGAAAATGATCCAGCTGAATTAGCTCATGCCCTTGGCGTAATTGCCAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGACGTGAAGCACTTTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCATTAGGCTTAAAACTCACTGTACAACACGCCCAAAACTTTAAAAAATATAGTAAAAATGGGAG
CTTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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