Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 38940..39564 Replicon plasmid pOXA58_005133
Accession NZ_CP026749
Organism Acinetobacter baumannii strain WCHAB005133

Toxin (Protein)


Gene name relE Uniprot ID N9CKJ9
Locus tag C5B74_RS00280 Protein ID WP_004647749.1
Coordinates 38940..39236 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C5B74_RS00285 Protein ID WP_104915067.1
Coordinates 39238..39564 (+) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B74_RS00245 35667..35912 + 246 WP_026438268.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C5B74_RS00250 35902..36195 + 294 WP_004733298.1 type II toxin-antitoxin system RelE/ParE family toxin -
C5B74_RS00255 36261..36575 - 315 WP_005108843.1 hypothetical protein -
C5B74_RS00260 36682..37113 + 432 WP_104915069.1 hypothetical protein -
C5B74_RS00265 37103..37429 + 327 WP_019838418.1 hypothetical protein -
C5B74_RS00275 37480..38699 + 1220 WP_104915068.1 IS3 family transposase -
C5B74_RS00280 38940..39236 + 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C5B74_RS00285 39238..39564 + 327 WP_104915067.1 putative addiction module antidote protein Antitoxin
C5B74_RS00290 39617..39820 - 204 WP_004896916.1 hypothetical protein -
C5B74_RS00300 40200..40511 + 312 WP_104915071.1 BrnT family toxin -
C5B74_RS00305 40474..40788 + 315 WP_019838467.1 BrnA antitoxin family protein -
C5B74_RS00310 40857..41360 - 504 WP_104915066.1 hypothetical protein -
C5B74_RS00315 41566..41922 + 357 Protein_50 type II toxin-antitoxin system RelE/ParE family toxin -
C5B74_RS00320 41915..42043 + 129 Protein_51 transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 / floR / sul2 - 1..42455 42455
- inside IScluster/Tn - - 37480..42454 4974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.25 Da        Isoelectric Point: 5.8801

>T95615 WP_004647749.1 NZ_CP026749:38940-39236 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T95615 NZ_CP026749:38940-39236 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTGCCAGAATTTGATGAATGGTTAGATGGCATTAAAGACAATATGACCCGTATTCGCCTAAA
TCGTAGACTAGATAAGGTTCAACGTGGAAATTGGGGAGACATTAAGCCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAGCATGGTGACGTAGTGATTGTAATGCTTGGAGGCGGAGATAAATCG
ACTCAACAACAAGACATTGATCGTGCAGTCAAACTATCGAAAACATTGGAGGATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11901.74 Da        Isoelectric Point: 7.2020

>AT95615 WP_104915067.1 NZ_CP026749:39238-39564 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNIVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHAQNFKKYSKNGSL

Download         Length: 327 bp

>AT95615 NZ_CP026749:39238-39564 [Acinetobacter baumannii]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
CATAGTTCTTGAAGAAAATGATCCAGCTGAATTAGCTCATGCCCTTGGCGTAATTGCCAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGACGTGAAGCACTTTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGATACGATT
AATCGTGTAGTAAATGCATTAGGCTTAAAACTCACTGTACAACACGCCCAAAACTTTAAAAAATATAGTAAAAATGGGAG
CTTATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References