Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2872405..2873096 Replicon chromosome
Accession NZ_CP026746
Organism Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C5B73_RS13470 Protein ID WP_104360457.1
Coordinates 2872405..2872800 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C5B73_RS13475 Protein ID WP_104360458.1
Coordinates 2872797..2873096 (-) Length 100 a.a.

Genomic Context

C5B73_RS13440C5B73_RS13445C5B73_RS13450C5B73_RS13480C5B73_RS13455C5B73_RS13470C5B73_RS13475C5B73_RS13485C5B73_RS29655
Location: 2868701..2869339 (639 bp)
Type: Others
Protein ID: WP_104360095.1
Location: 2869370..2869720 (351 bp)
Type: Others
Protein ID: WP_104897942.1
Location: 2869875..2870231 (357 bp)
Type: Others
Protein ID: WP_036539777.1
Location: 2873210..2875234 (2025 bp)
Type: Others
Protein ID: WP_104360544.1
Location: 2870259..2870810 (552 bp)
Type: Others
Protein ID: WP_104362287.1
Location: 2872405..2872800 (396 bp)
Type: Toxin
Protein ID: WP_104360457.1
Location: 2872797..2873096 (300 bp)
Type: Antitoxin
Protein ID: WP_104360458.1
Location: 2875417..2876322 (906 bp)
Type: Others
Protein ID: WP_104360459.1
Location: 2876319..2876486 (168 bp)
Type: Others
Protein ID: WP_158682476.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C5B73_RS134402868701..2869339+639WP_104360095.1glyoxalase-
C5B73_RS134452869370..2869720+351WP_104897942.1VOC family protein-
C5B73_RS134502869875..2870231+357WP_036539777.1DoxX family protein-
C5B73_RS134552870259..2870810-552WP_104362287.1hypothetical protein-
C5B73_RS134702872405..2872800-396WP_104360457.1type II toxin-antitoxin system VapC family toxinToxin
C5B73_RS134752872797..2873096-300WP_104360458.1prevent-host-death proteinAntitoxin
C5B73_RS134802873210..2875234+2025WP_104360544.1thioredoxin domain-containing protein-
C5B73_RS134852875417..2876322-906WP_104360459.1phosphatidylinositol mannoside acyltransferase-
C5B73_RS296552876319..2876486-168WP_158682476.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14253.45 Da        Isoelectric Point: 4.4277

>T95613 WP_104360457.1 NZ_CP026746:c2872800-2872405 [Nocardia cyriacigeorgica]
MRLYLDTSALVKLVHPEAETDALLRWLEERPDQPWVASALVEAELVRAVRMAEPADLIHIPAVLARLDMVEIDGIVRANA
EAISPANVRSLDAIHLATALELATDLTGLVAYDKRLGEAAEAAGLTWIAPR

Download         Length: 396 bp

>T95613 NZ_CP026746:c2872800-2872405 [Nocardia cyriacigeorgica]
CTGAGGCTCTACCTGGACACCAGCGCACTGGTCAAACTGGTCCACCCGGAAGCCGAGACCGACGCGCTCTTGCGCTGGCT
CGAGGAACGACCCGACCAGCCCTGGGTAGCGTCCGCCCTCGTCGAGGCCGAACTGGTCCGTGCCGTGCGGATGGCCGAAC
CAGCGGACCTCATTCACATCCCCGCCGTTCTCGCACGACTCGACATGGTGGAAATCGATGGCATCGTCCGAGCGAACGCA
GAGGCGATTTCACCGGCAAACGTGCGCAGTCTCGACGCGATACACCTCGCCACAGCTCTCGAACTGGCCACAGACCTCAC
CGGACTGGTCGCATATGACAAGCGCCTGGGCGAGGCCGCCGAAGCCGCCGGATTGACCTGGATCGCACCTCGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10767.21 Da        Isoelectric Point: 10.3396

>AT95613 WP_104360458.1 NZ_CP026746:c2873096-2872797 [Nocardia cyriacigeorgica]
MTAIPIRELSHHTARTLALVKAGETVDITERGTIIGRIVPVDPTRDARARLTAEGRMRPASRGRADLLADIRRRADPAAA
DDPTGVSAALQELRDGERY

Download         Length: 300 bp

>AT95613 NZ_CP026746:c2873096-2872797 [Nocardia cyriacigeorgica]
ATGACCGCCATTCCGATTCGCGAACTGTCGCATCACACCGCACGGACGTTGGCGCTGGTCAAGGCGGGTGAGACAGTCGA
CATCACCGAGCGCGGAACGATCATCGGCCGAATTGTGCCGGTCGATCCGACGCGTGACGCACGGGCTCGCCTGACGGCCG
AAGGGCGAATGCGCCCCGCATCCAGGGGCCGCGCAGATCTACTCGCCGATATTCGCCGCCGAGCCGACCCGGCAGCCGCC
GACGACCCGACCGGCGTCAGCGCGGCATTGCAGGAACTGCGCGACGGCGAGCGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References