Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2872405..2873096 Replicon chromosome
Accession NZ_CP026746
Organism Nocardia cyriacigeorgica strain MDA3349 isolate MDA3349 ancestor

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C5B73_RS13470 Protein ID WP_104360457.1
Coordinates 2872405..2872800 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C5B73_RS13475 Protein ID WP_104360458.1
Coordinates 2872797..2873096 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B73_RS13440 2868701..2869339 + 639 WP_104360095.1 glyoxalase -
C5B73_RS13445 2869370..2869720 + 351 WP_104897942.1 VOC family protein -
C5B73_RS13450 2869875..2870231 + 357 WP_036539777.1 DoxX family protein -
C5B73_RS13455 2870259..2870810 - 552 WP_104362287.1 hypothetical protein -
C5B73_RS13470 2872405..2872800 - 396 WP_104360457.1 type II toxin-antitoxin system VapC family toxin Toxin
C5B73_RS13475 2872797..2873096 - 300 WP_104360458.1 prevent-host-death protein Antitoxin
C5B73_RS13480 2873210..2875234 + 2025 WP_104360544.1 thioredoxin domain-containing protein -
C5B73_RS13485 2875417..2876322 - 906 WP_104360459.1 phosphatidylinositol mannoside acyltransferase -
C5B73_RS29655 2876319..2876486 - 168 WP_158682476.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14253.45 Da        Isoelectric Point: 4.4277

>T95613 WP_104360457.1 NZ_CP026746:c2872800-2872405 [Nocardia cyriacigeorgica]
MRLYLDTSALVKLVHPEAETDALLRWLEERPDQPWVASALVEAELVRAVRMAEPADLIHIPAVLARLDMVEIDGIVRANA
EAISPANVRSLDAIHLATALELATDLTGLVAYDKRLGEAAEAAGLTWIAPR

Download         Length: 396 bp

>T95613 NZ_CP026746:c2872800-2872405 [Nocardia cyriacigeorgica]
CTGAGGCTCTACCTGGACACCAGCGCACTGGTCAAACTGGTCCACCCGGAAGCCGAGACCGACGCGCTCTTGCGCTGGCT
CGAGGAACGACCCGACCAGCCCTGGGTAGCGTCCGCCCTCGTCGAGGCCGAACTGGTCCGTGCCGTGCGGATGGCCGAAC
CAGCGGACCTCATTCACATCCCCGCCGTTCTCGCACGACTCGACATGGTGGAAATCGATGGCATCGTCCGAGCGAACGCA
GAGGCGATTTCACCGGCAAACGTGCGCAGTCTCGACGCGATACACCTCGCCACAGCTCTCGAACTGGCCACAGACCTCAC
CGGACTGGTCGCATATGACAAGCGCCTGGGCGAGGCCGCCGAAGCCGCCGGATTGACCTGGATCGCACCTCGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10767.21 Da        Isoelectric Point: 10.3396

>AT95613 WP_104360458.1 NZ_CP026746:c2873096-2872797 [Nocardia cyriacigeorgica]
MTAIPIRELSHHTARTLALVKAGETVDITERGTIIGRIVPVDPTRDARARLTAEGRMRPASRGRADLLADIRRRADPAAA
DDPTGVSAALQELRDGERY

Download         Length: 300 bp

>AT95613 NZ_CP026746:c2873096-2872797 [Nocardia cyriacigeorgica]
ATGACCGCCATTCCGATTCGCGAACTGTCGCATCACACCGCACGGACGTTGGCGCTGGTCAAGGCGGGTGAGACAGTCGA
CATCACCGAGCGCGGAACGATCATCGGCCGAATTGTGCCGGTCGATCCGACGCGTGACGCACGGGCTCGCCTGACGGCCG
AAGGGCGAATGCGCCCCGCATCCAGGGGCCGCGCAGATCTACTCGCCGATATTCGCCGCCGAGCCGACCCGGCAGCCGCC
GACGACCCGACCGGCGTCAGCGCGGCATTGCAGGAACTGCGCGACGGCGAGCGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References