Detailed information of TA system TA095607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2405798..2406396
• Replicon: chromosome
• Accession: NZ_CP026729
• Organism: Bifidobacterium catenulatum subsp. kashiwanohense strain APCKJ1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0A7I4S3
• Locus tag: BKKJ1_RS10520
• Protein ID: WP_033501891.1
• Coordinates: 2405798..2406109 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BKKJ1_RS10525
• Protein ID: WP_033501886.1
• Coordinates: 2406103..2406396 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKKJ1_RS10505	2402009..2402986	-	978	WP_033501883.1	carbohydrate ABC transporter permease	-
BKKJ1_RS10510	2402986..2403897	-	912	WP_100969227.1	sugar ABC transporter permease	-
BKKJ1_RS10515	2404257..2405300	+	1044	WP_154304336.1	LacI family DNA-binding transcriptional regulator	-
BKKJ1_RS10520	2405798..2406109	+	312	WP_033501891.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BKKJ1_RS10525	2406103..2406396	+	294	WP_033501886.1	putative addiction module antidote protein	Antitoxin
BKKJ1_RS10530	2406703..2408469	-	1767	WP_154304337.1	FAD-dependent oxidoreductase	-
BKKJ1_RS10535	2408572..2409135	-	564	WP_033501889.1	peroxiredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-89)

Antitoxin

• Uncharacterized protein HI1420 (6-89)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11769.66 Da
• Isoelectric Point: 10.5847

>T95607 WP_033501891.1 NZ_CP026729:2405798-2406109 [Bifidobacterium catenulatum subsp. kashiwanohense]
MEIQQTDQFRKWLHRLRDHAAKARITARIRQCALAGQPVGDMHPVGKGVNELRFFFGPGYRVYFAQKGNQIMLLLAGGDK
TGQDKTIKEAQKMLESLIKEGQW

Nucleotide

• Length: 312 bp

>T95607 NZ_CP026729:2405798-2406109 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATGGAAATCCAACAAACCGACCAGTTCCGCAAGTGGTTGCATAGGCTGCGCGACCATGCCGCCAAAGCGCGGATCACTGC
CCGGATCAGACAGTGTGCACTGGCGGGACAACCGGTCGGCGATATGCACCCGGTCGGTAAAGGCGTGAACGAATTGCGTT
TCTTCTTCGGCCCAGGCTACCGCGTCTACTTCGCCCAGAAAGGCAATCAAATCATGTTGCTGCTCGCCGGCGGGGACAAG
ACCGGACAGGACAAGACCATAAAAGAGGCACAGAAAATGCTCGAATCACTTATCAAGGAGGGACAATGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10150.46 Da
• Isoelectric Point: 4.3094

>AT95607 WP_033501886.1 NZ_CP026729:2406103-2406396 [Bifidobacterium catenulatum subsp. kashiwanohense]
MVSISNFDASEYIENEEDAIAYLNAAAETGDPALLQAAIGDIAKARGMGQIAKEAGVGRESLYKSLNKEGNPSFRTIVKV
VDALGGRLVIEPVPATA

Nucleotide

• Length: 294 bp

>AT95607 NZ_CP026729:2406103-2406396 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATGGTAAGCATCAGCAATTTTGATGCCAGCGAATACATCGAAAACGAAGAAGACGCCATCGCATACCTCAACGCCGCCGC
GGAAACCGGCGACCCGGCGCTTCTGCAGGCCGCCATCGGCGACATAGCCAAGGCGCGTGGCATGGGCCAAATCGCCAAGG
AAGCCGGAGTCGGCCGCGAAAGCCTCTACAAAAGCCTCAACAAAGAAGGCAACCCAAGTTTCCGCACCATCGTCAAGGTC
GTCGATGCACTTGGAGGCCGACTTGTCATCGAACCCGTGCCCGCCACGGCATGA

Structures

Toxin

• AlphaFold DB: A0A0A7I4S3