Detailed information of TA system TA095606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 2196929..2197800
• Replicon: chromosome
• Accession: NZ_CP026729
• Organism: Bifidobacterium catenulatum subsp. kashiwanohense strain APCKJ1

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: BKKJ1_RS09745
• Protein ID: WP_154304225.1
• Coordinates: 2197483..2197800 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A087B0P0
• Locus tag: BKKJ1_RS09740
• Protein ID: WP_051920327.1
• Coordinates: 2196929..2197483 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKKJ1_RS09730	2193037..2193987	+	951	WP_033501484.1	glycosyltransferase family 2 protein	-
BKKJ1_RS09735	2194056..2196659	-	2604	WP_154304223.1	RICIN domain-containing protein	-
BKKJ1_RS09740	2196929..2197483	+	555	WP_051920327.1	DUF4065 domain-containing protein	Antitoxin
BKKJ1_RS09745	2197483..2197800	+	318	WP_154304225.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BKKJ1_RS09750	2198078..2198992	+	915	WP_193564494.1	hypothetical protein	-
BKKJ1_RS09755	2199144..2200769	+	1626	WP_154304429.1	sialate O-acetylesterase	-
BKKJ1_RS09760	2200892..2201248	-	357	WP_154304227.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2174822..2202427	27605

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-100)

Antitoxin

• Antitoxin SocA-like, Panacea domain (31-126)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12649.76 Da
• Isoelectric Point: 9.3332

>T95606 WP_154304225.1 NZ_CP026729:2197483-2197800 [Bifidobacterium catenulatum subsp. kashiwanohense]
MQPRPWQIWKVWFPFRENPSAGKYRPVVIKEVTEDNCVVIYITSQVEKTHFPDFMLIHNWDEAGLTKASAIRYRRMLKIP
IDQLENYMGTLSPYDRIELQMKYLK

Nucleotide

• Length: 318 bp

>T95606 NZ_CP026729:2197483-2197800 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATGCAGCCGCGTCCTTGGCAAATTTGGAAAGTTTGGTTCCCATTCAGAGAAAACCCTTCCGCAGGAAAATATCGACCCGT
TGTTATCAAAGAAGTCACCGAAGATAATTGCGTAGTAATCTACATTACGTCCCAAGTTGAAAAAACGCATTTTCCGGACT
TCATGCTTATCCACAATTGGGATGAAGCAGGTCTCACAAAAGCTTCAGCCATCCGCTACAGAAGGATGTTGAAAATCCCA
ATCGATCAGTTGGAAAACTACATGGGAACACTTTCGCCATACGATCGTATCGAACTCCAAATGAAATATCTAAAGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 21162.03 Da
• Isoelectric Point: 4.3019

>AT95606 WP_051920327.1 NZ_CP026729:2196929-2197483 [Bifidobacterium catenulatum subsp. kashiwanohense]
MLNVMDVADFFIATANEGDPEEDDGMTNMKLNKLLFFAQAASLQRFGKPLFDAPLEAWKYGPVVKSVYRTFKECQRDSIA
KVAQPFDWQTIPPETLDLLCDVYRTYARDYSAMGLMRKTHQPDTPWSETYVPNENKVIPVESIQKWVQKQPLPIDMQPEP
DKNIIVAELDSQGRPFLPEGWEDD

Nucleotide

• Length: 555 bp

>AT95606 NZ_CP026729:2196929-2197483 [Bifidobacterium catenulatum subsp. kashiwanohense]
ATGCTGAACGTTATGGACGTTGCCGATTTCTTCATCGCAACCGCCAACGAAGGCGATCCGGAAGAAGATGACGGCATGAC
CAATATGAAACTCAACAAGCTCCTGTTTTTTGCACAGGCAGCAAGCCTGCAACGATTCGGCAAACCCTTGTTCGACGCAC
CCCTCGAAGCTTGGAAATATGGCCCTGTCGTCAAAAGCGTATATCGGACGTTTAAGGAATGTCAGCGCGATTCCATCGCG
AAAGTCGCCCAACCTTTCGACTGGCAGACGATTCCACCGGAAACTTTGGATCTGCTGTGCGACGTATACCGCACATACGC
ACGGGATTATTCCGCAATGGGACTCATGCGCAAAACACACCAGCCTGACACCCCTTGGTCGGAAACTTATGTCCCTAATG
AGAACAAAGTCATCCCAGTTGAAAGCATCCAAAAATGGGTCCAAAAACAGCCTTTGCCTATCGACATGCAGCCCGAACCC
GATAAAAACATCATCGTTGCCGAGCTTGACTCGCAAGGACGTCCGTTCCTCCCCGAAGGTTGGGAGGATGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A087B0P0