Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5180772..5181567 Replicon chromosome
Accession NZ_CP026723
Organism Escherichia coli strain 266917_2

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C4R22_RS26680 Protein ID WP_000854914.1
Coordinates 5181193..5181567 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag C4R22_RS26675 Protein ID WP_001280955.1
Coordinates 5180772..5181146 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4R22_RS26635 5176127..5177032 + 906 WP_023149949.1 hypothetical protein -
C4R22_RS26640 5177029..5178099 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
C4R22_RS26655 5178439..5179257 + 819 WP_001234682.1 DUF945 domain-containing protein -
C4R22_RS26660 5179348..5179833 + 486 WP_000214398.1 antirestriction protein -
C4R22_RS26665 5179849..5180325 + 477 WP_001186726.1 RadC family protein -
C4R22_RS26670 5180388..5180609 + 222 WP_001220314.1 DUF987 domain-containing protein -
C4R22_RS26675 5180772..5181146 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C4R22_RS26680 5181193..5181567 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C4R22_RS26685 5181564..5182055 + 492 WP_000976857.1 hypothetical protein -
C4R22_RS26690 5182067..5182264 + 198 WP_032278113.1 DUF957 domain-containing protein -
C4R22_RS26695 5182349..5183191 + 843 WP_001280481.1 DUF4942 domain-containing protein -
C4R22_RS26705 5183662..5184600 + 939 WP_001550942.1 glyoxylate/hydroxypyruvate reductase GhrA -
C4R22_RS26710 5184655..5185392 + 738 WP_000283664.1 zinc-binding phosphatase -
C4R22_RS26715 5185416..5185970 + 555 WP_001001909.1 molecular chaperone YcdY -
C4R22_RS26720 5186072..5186563 + 492 WP_032145787.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T95584 WP_000854914.1 NZ_CP026723:5181193-5181567 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T95584 NZ_CP026723:5181193-5181567 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATATGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT95584 WP_001280955.1 NZ_CP026723:5180772-5181146 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT95584 NZ_CP026723:5180772-5181146 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References