Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3625678..3626273 Replicon chromosome
Accession NZ_CP026723
Organism Escherichia coli strain 266917_2

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag C4R22_RS18625 Protein ID WP_019842229.1
Coordinates 3625923..3626273 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag C4R22_RS18620 Protein ID WP_001223213.1
Coordinates 3625678..3625929 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4R22_RS18610 3621343..3625122 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
C4R22_RS18615 3625125..3625466 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
C4R22_RS18620 3625678..3625929 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C4R22_RS18625 3625923..3626273 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
C4R22_RS18630 3626477..3627007 - 531 WP_000055075.1 inorganic diphosphatase -
C4R22_RS18635 3627317..3628273 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C4R22_RS18640 3628405..3629907 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
C4R22_RS18645 3629921..3630943 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T95575 WP_019842229.1 NZ_CP026723:3625923-3626273 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T95575 NZ_CP026723:3625923-3626273 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT95575 WP_001223213.1 NZ_CP026723:3625678-3625929 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT95575 NZ_CP026723:3625678-3625929 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References