Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1116422..1117079 Replicon chromosome
Accession NZ_CP026719
Organism Enterobacter cloacae complex sp. strain AR_0060

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag AM439_RS05420 Protein ID WP_017382887.1
Coordinates 1116422..1116832 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM439_RS05425 Protein ID WP_003863437.1
Coordinates 1116813..1117079 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM439_RS05400 (AM439_05395) 1112420..1114153 - 1734 WP_049132792.1 single-stranded-DNA-specific exonuclease RecJ -
AM439_RS05405 (AM439_05400) 1114159..1114872 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM439_RS05410 (AM439_05405) 1114901..1115797 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM439_RS05415 (AM439_05410) 1115899..1116420 + 522 WP_015571793.1 flavodoxin FldB -
AM439_RS05420 (AM439_05415) 1116422..1116832 - 411 WP_017382887.1 protein YgfX Toxin
AM439_RS05425 (AM439_05420) 1116813..1117079 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM439_RS05430 (AM439_05425) 1117374..1118354 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
AM439_RS05435 (AM439_05430) 1118466..1119125 - 660 WP_003863433.1 hemolysin III family protein -
AM439_RS05440 (AM439_05435) 1119392..1120123 + 732 WP_104879725.1 MurR/RpiR family transcriptional regulator -
AM439_RS05445 (AM439_05440) 1120240..1121673 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T95540 WP_017382887.1 NZ_CP026719:c1116832-1116422 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T95540 NZ_CP026719:c1116832-1116422 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT95540 WP_003863437.1 NZ_CP026719:c1117079-1116813 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT95540 NZ_CP026719:c1117079-1116813 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References