Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5733650..5734307 Replicon chromosome
Accession NZ_CP026715
Organism Klebsiella oxytoca strain AR_0028

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag AM355_RS27710 Protein ID WP_004854060.1
Coordinates 5733897..5734307 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag AM355_RS27705 Protein ID WP_004124953.1
Coordinates 5733650..5733916 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM355_RS27690 5728884..5729309 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
AM355_RS27695 5729430..5732228 - 2799 WP_104876987.1 transcriptional regulator DagR -
AM355_RS27700 5732422..5733405 - 984 WP_085520149.1 tRNA-modifying protein YgfZ -
AM355_RS27705 5733650..5733916 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
AM355_RS27710 5733897..5734307 + 411 WP_004854060.1 protein YgfX Toxin
AM355_RS27715 5734316..5734837 - 522 WP_014226792.1 flavodoxin FldB -
AM355_RS27720 5734959..5735855 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
AM355_RS27725 5735878..5736591 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM355_RS27730 5736597..5738330 + 1734 WP_049101946.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T95528 WP_004854060.1 NZ_CP026715:5733897-5734307 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T95528 NZ_CP026715:5733897-5734307 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT95528 WP_004124953.1 NZ_CP026715:5733650-5733916 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95528 NZ_CP026715:5733650-5733916 [Klebsiella oxytoca]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGATAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References