Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1494361..1495012 Replicon chromosome
Accession NZ_CP026711
Organism Acinetobacter baumannii strain AR_0063

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AM442_RS07385 Protein ID WP_000838146.1
Coordinates 1494361..1494543 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag AM442_RS07390 Protein ID WP_000966689.1
Coordinates 1494608..1495012 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM442_RS07340 1489444..1490109 + 666 WP_057048505.1 stress-responsive nuclear envelope protein -
AM442_RS07345 1490114..1490503 + 390 WP_057048504.1 hypothetical protein -
AM442_RS07350 1490507..1490875 + 369 WP_032046655.1 hypothetical protein -
AM442_RS19985 1490875..1491045 + 171 WP_171252300.1 hypothetical protein -
AM442_RS07355 1491056..1491460 + 405 WP_057048503.1 hypothetical protein -
AM442_RS07360 1491432..1491800 + 369 WP_000539752.1 hypothetical protein -
AM442_RS07365 1491802..1492200 + 399 WP_001132270.1 hypothetical protein -
AM442_RS07370 1492202..1492414 + 213 WP_000121166.1 hypothetical protein -
AM442_RS07375 1492522..1493451 + 930 WP_057048502.1 hypothetical protein -
AM442_RS07380 1493496..1494029 + 534 WP_001185622.1 hypothetical protein -
AM442_RS07385 1494361..1494543 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AM442_RS07390 1494608..1495012 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM442_RS07395 1495108..1495626 + 519 WP_001168930.1 DUF4468 domain-containing protein -
AM442_RS07400 1495723..1499784 + 4062 WP_057048501.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1463996..1520682 56686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T95513 WP_000838146.1 NZ_CP026711:1494361-1494543 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T95513 NZ_CP026711:1494361-1494543 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT95513 WP_000966689.1 NZ_CP026711:1494608-1495012 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT95513 NZ_CP026711:1494608-1495012 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References