Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 87925..88578 Replicon chromosome
Accession NZ_CP026711
Organism Acinetobacter baumannii strain AR_0063

Toxin (Protein)


Gene name cptA Uniprot ID A0A427QZH0
Locus tag AM442_RS00465 Protein ID WP_000931891.1
Coordinates 87925..88314 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag AM442_RS00470 Protein ID WP_001288210.1
Coordinates 88321..88578 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM442_RS00450 83047..85238 - 2192 Protein_74 TRAP transporter large permease subunit -
AM442_RS00455 85426..85992 - 567 WP_000651536.1 rhombosortase -
AM442_RS00460 86070..87155 - 1086 WP_000049104.1 hypothetical protein -
AM442_RS00465 87925..88314 - 390 WP_000931891.1 hypothetical protein Toxin
AM442_RS00470 88321..88578 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
AM442_RS00475 88766..89938 + 1173 WP_001190558.1 acyl-CoA dehydrogenase family protein -
AM442_RS00480 89988..91478 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
AM442_RS00485 91660..92037 - 378 WP_001216380.1 50S ribosomal protein L17 -
AM442_RS00490 92056..93063 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T95512 WP_000931891.1 NZ_CP026711:c88314-87925 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T95512 NZ_CP026711:c88314-87925 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCGCAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT95512 WP_001288210.1 NZ_CP026711:c88578-88321 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT95512 NZ_CP026711:c88578-88321 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A427QZH0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References