Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4302928..4303582 Replicon chromosome
Accession NZ_CP026709
Organism Citrobacter koseri strain AR_0024

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag AM351_RS21110 Protein ID WP_024130921.1
Coordinates 4302928..4303335 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag AM351_RS21115 Protein ID WP_024130922.1
Coordinates 4303316..4303582 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM351_RS21090 4298830..4300563 - 1734 WP_049008966.1 single-stranded-DNA-specific exonuclease RecJ -
AM351_RS21095 4300569..4301282 - 714 WP_012134997.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM351_RS21100 4301306..4302202 - 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
AM351_RS21105 4302306..4302830 + 525 WP_012134999.1 flavodoxin FldB -
AM351_RS21110 4302928..4303335 - 408 WP_024130921.1 protein YgfX Toxin
AM351_RS21115 4303316..4303582 - 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
AM351_RS21125 4303839..4304819 + 981 WP_058668058.1 tRNA-modifying protein YgfZ -
AM351_RS21130 4304973..4305632 - 660 WP_058668059.1 hemolysin III family protein -
AM351_RS21135 4305794..4306105 - 312 WP_012135005.1 N(4)-acetylcytidine aminohydrolase -
AM351_RS21140 4306158..4306886 + 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
AM351_RS21145 4307007..4308440 + 1434 WP_058668060.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T95511 WP_024130921.1 NZ_CP026709:c4303335-4302928 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T95511 NZ_CP026709:c4303335-4302928 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGTCCGCCCTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGCCA
GCACTTGTGGCTGGCGGCGGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT95511 WP_024130922.1 NZ_CP026709:c4303582-4303316 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95511 NZ_CP026709:c4303582-4303316 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGTGATGCAGAGCTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References