Detailed information of TA system TA095510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3405702..3406294
• Replicon: chromosome
• Accession: NZ_CP026709
• Organism: Citrobacter koseri strain AR_0024

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AM351_RS16555
• Protein ID: WP_058669399.1
• Coordinates: 3406040..3406294 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AM351_RS16550
• Protein ID: WP_058669398.1
• Coordinates: 3405702..3406043 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM351_RS16540	3401816..3404410	-	2595	WP_058669397.1	SIR2 family protein	-
AM351_RS16545	3404911..3405558	-	648	Protein_3107	phage portal protein	-
AM351_RS16550	3405702..3406043	-	342	WP_058669398.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AM351_RS16555	3406040..3406294	-	255	WP_058669399.1	type II toxin-antitoxin system HicA family toxin	Toxin
AM351_RS16560	3406702..3407601	+	900	WP_012131675.1	lipid kinase YegS	-
AM351_RS16565	3407680..3408342	-	663	WP_058669400.1	HAD-IA family hydrolase	-
AM351_RS16570	3408391..3409668	-	1278	WP_012131672.1	RbtT/DalT/CsbX family MFS transporter	-
AM351_RS16575	3409736..3411199	-	1464	WP_058669401.1	xylulokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-99)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9468.02 Da
• Isoelectric Point: 10.8834

>T95510 WP_058669399.1 NZ_CP026709:c3406294-3406040 [Citrobacter koseri]
MNKRHLKTLSDVFARPIRSSIKWSDIESMLIALGAEIHEREGSRIAVALKGEKKIFHRPHPQPTTDKGAVNSLRIWLESL
GVTP

Nucleotide

• Length: 255 bp

>T95510 NZ_CP026709:c3406294-3406040 [Citrobacter koseri]
ATGAATAAACGACACCTTAAAACGCTATCAGATGTGTTTGCCCGCCCAATCAGAAGCTCAATAAAGTGGTCTGATATTGA
GTCAATGCTTATTGCGTTGGGCGCGGAGATTCACGAACGAGAAGGTTCAAGGATTGCGGTTGCACTGAAAGGTGAGAAGA
AAATCTTTCACAGGCCACACCCGCAGCCAACCACTGATAAGGGGGCGGTAAACTCTCTTCGGATATGGCTTGAAAGTTTA
GGAGTAACGCCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12609.32 Da
• Isoelectric Point: 4.6229

>AT95510 WP_058669398.1 NZ_CP026709:c3406043-3405702 [Citrobacter koseri]
MINVLKIDGHQAVITFDPEIEMFRGEFIGLNGGADFYAYSVEELKKEGAESLRIFLDECRKDGIEPYKSYSGKVTTRLTP
ERHEALTIAAQATGMSINEMLNEGVDLVIARHS

Nucleotide

• Length: 342 bp

>AT95510 NZ_CP026709:c3406043-3405702 [Citrobacter koseri]
ATGATTAATGTACTTAAAATCGACGGCCATCAGGCCGTCATCACCTTTGACCCAGAAATCGAAATGTTTCGCGGTGAATT
TATTGGGCTTAACGGTGGTGCCGACTTCTACGCTTACAGCGTGGAAGAATTGAAAAAAGAAGGCGCTGAGTCGCTTCGTA
TCTTCCTGGATGAATGCAGAAAGGACGGTATTGAGCCTTATAAATCCTATAGCGGAAAAGTTACAACCCGTCTGACGCCT
GAGCGGCATGAAGCGTTGACTATTGCAGCGCAGGCTACAGGTATGTCTATTAATGAAATGCTGAATGAAGGTGTTGACCT
CGTTATCGCGCGTCATTCATAA