Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2623961..2624600 | Replicon | chromosome |
Accession | NZ_CP026709 | ||
Organism | Citrobacter koseri strain AR_0024 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | AM351_RS12785 | Protein ID | WP_072271874.1 |
Coordinates | 2624424..2624600 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | AM351_RS12780 | Protein ID | WP_125337124.1 |
Coordinates | 2623961..2624377 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM351_RS12760 | 2620198..2620371 | - | 174 | WP_049008504.1 | GhoT/OrtT family toxin | - |
AM351_RS12765 | 2620563..2620658 | + | 96 | WP_071818853.1 | stress response membrane protein YncL | - |
AM351_RS12770 | 2620757..2622181 | - | 1425 | WP_060816081.1 | aminobutyraldehyde dehydrogenase | - |
AM351_RS12775 | 2622501..2623910 | - | 1410 | WP_058669185.1 | PLP-dependent aminotransferase family protein | - |
AM351_RS12780 | 2623961..2624377 | - | 417 | WP_125337124.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
AM351_RS12785 | 2624424..2624600 | - | 177 | WP_072271874.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
AM351_RS12790 | 2624820..2626781 | - | 1962 | WP_058669433.1 | U32 family peptidase | - |
AM351_RS12795 | 2626860..2627396 | - | 537 | WP_058669186.1 | XRE family transcriptional regulator | - |
AM351_RS12800 | 2627489..2628655 | + | 1167 | WP_058669187.1 | benzoate/H(+) symporter BenE family transporter | - |
AM351_RS12805 | 2628632..2629507 | - | 876 | WP_012132344.1 | AraC family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6794.76 Da Isoelectric Point: 10.8122
>T95501 WP_072271874.1 NZ_CP026709:c2624600-2624424 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQPGLN
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQPGLN
Download Length: 177 bp
>T95501 NZ_CP026709:c2624600-2624424 [Citrobacter koseri]
GTGAAGCAAAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAGCGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCCTGGTTTGAATTAA
GTGAAGCAAAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAGCGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCCTGGTTTGAATTAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15370.62 Da Isoelectric Point: 4.4377
>AT95501 WP_125337124.1 NZ_CP026709:c2624377-2623961 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML
Download Length: 417 bp
>AT95501 NZ_CP026709:c2624377-2623961 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAATCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTTAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATCGATGCTGTACAGATTGCGGCCAGAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAATCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTTAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATCGATGCTGTACAGATTGCGGCCAGAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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