Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2623961..2624600 Replicon chromosome
Accession NZ_CP026709
Organism Citrobacter koseri strain AR_0024

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AM351_RS12785 Protein ID WP_072271874.1
Coordinates 2624424..2624600 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM351_RS12780 Protein ID WP_125337124.1
Coordinates 2623961..2624377 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM351_RS12760 2620198..2620371 - 174 WP_049008504.1 GhoT/OrtT family toxin -
AM351_RS12765 2620563..2620658 + 96 WP_071818853.1 stress response membrane protein YncL -
AM351_RS12770 2620757..2622181 - 1425 WP_060816081.1 aminobutyraldehyde dehydrogenase -
AM351_RS12775 2622501..2623910 - 1410 WP_058669185.1 PLP-dependent aminotransferase family protein -
AM351_RS12780 2623961..2624377 - 417 WP_125337124.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM351_RS12785 2624424..2624600 - 177 WP_072271874.1 type II toxin-antitoxin system HicA family toxin Toxin
AM351_RS12790 2624820..2626781 - 1962 WP_058669433.1 U32 family peptidase -
AM351_RS12795 2626860..2627396 - 537 WP_058669186.1 XRE family transcriptional regulator -
AM351_RS12800 2627489..2628655 + 1167 WP_058669187.1 benzoate/H(+) symporter BenE family transporter -
AM351_RS12805 2628632..2629507 - 876 WP_012132344.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6794.76 Da        Isoelectric Point: 10.8122

>T95501 WP_072271874.1 NZ_CP026709:c2624600-2624424 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQPGLN

Download         Length: 177 bp

>T95501 NZ_CP026709:c2624600-2624424 [Citrobacter koseri]
GTGAAGCAAAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAGCGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCCTGGTTTGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15370.62 Da        Isoelectric Point: 4.4377

>AT95501 WP_125337124.1 NZ_CP026709:c2624377-2623961 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT95501 NZ_CP026709:c2624377-2623961 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAATCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTTAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATCGATGCTGTACAGATTGCGGCCAGAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References