Detailed information of TA system TA095495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3541086..3541765
• Replicon: chromosome
• Accession: NZ_CP026707
• Organism: Acinetobacter baumannii strain AR_0056

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AM435_RS18455
• Protein ID: WP_000838146.1
• Coordinates: 3541086..3541268 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AM435_RS18460
• Protein ID: WP_000966688.1
• Coordinates: 3541361..3541765 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM435_RS18410	3536241..3536648	+	408	WP_000255076.1	hypothetical protein	-
AM435_RS18415	3536620..3536988	+	369	WP_025466445.1	hypothetical protein	-
AM435_RS18420	3536990..3537388	+	399	WP_025466443.1	hypothetical protein	-
AM435_RS18425	3537390..3537608	+	219	WP_001277694.1	hypothetical protein	-
AM435_RS18430	3537704..3538057	+	354	WP_031975507.1	hypothetical protein	-
AM435_RS18435	3538057..3539205	+	1149	WP_033841386.1	hypothetical protein	-
AM435_RS18440	3539258..3540175	+	918	WP_033841385.1	hypothetical protein	-
AM435_RS18445	3540245..3540760	+	516	WP_032014679.1	hypothetical protein	-
AM435_RS18455	3541086..3541268	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AM435_RS18460	3541361..3541765	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AM435_RS18465	3541864..3542544	+	681	WP_000721572.1	hypothetical protein	-
AM435_RS18470	3542546..3542809	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	tufA / pilU / pilT	3448565..3580606	132041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T95495 WP_000838146.1 NZ_CP026707:3541086-3541268 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T95495 NZ_CP026707:3541086-3541268 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT95495 WP_000966688.1 NZ_CP026707:3541361-3541765 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT95495 NZ_CP026707:3541361-3541765 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6