Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 760511..761162 Replicon chromosome
Accession NZ_CP026704
Organism Providencia stuartii strain AR_0026

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag AM353_RS03470 Protein ID WP_004927064.1
Coordinates 760959..761162 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag AM353_RS03465 Protein ID WP_004927067.1
Coordinates 760511..760879 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM353_RS03440 755648..756409 - 762 WP_004927092.1 DNA polymerase III subunit epsilon -
AM353_RS03445 756464..756934 + 471 WP_104872987.1 ribonuclease HI -
AM353_RS03450 757013..757738 - 726 WP_053110025.1 methyltransferase domain-containing protein -
AM353_RS03455 757772..758527 + 756 WP_014656763.1 hydroxyacylglutathione hydrolase -
AM353_RS03460 758606..759943 + 1338 WP_004927077.1 murein transglycosylase D -
AM353_RS03465 760511..760879 + 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
AM353_RS03470 760959..761162 + 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
AM353_RS03480 761768..762226 - 459 WP_004927062.1 YbaY family lipoprotein -
AM353_RS03485 762548..763414 + 867 WP_004927058.1 acyl-CoA thioesterase II -
AM353_RS03490 763651..764934 - 1284 WP_014656764.1 ammonium transporter AmtB -
AM353_RS03495 764945..765283 - 339 WP_004927053.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T95492 WP_004927064.1 NZ_CP026704:760959-761162 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T95492 NZ_CP026704:760959-761162 [Providencia stuartii]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT95492 WP_004927067.1 NZ_CP026704:760511-760879 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT95492 NZ_CP026704:760511-760879 [Providencia stuartii]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGTT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References