Detailed information of TA system TA095488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4557888..4558544
• Replicon: chromosome
• Accession: NZ_CP026702
• Organism: Serratia marcescens strain AR_0027

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: AM354_RS21800
• Protein ID: WP_041036282.1
• Coordinates: 4558155..4558544 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: AM354_RS21795
• Protein ID: WP_004941563.1
• Coordinates: 4557888..4558151 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM354_RS21775	4552966..4554015	-	1050	WP_033635553.1	class I fructose-bisphosphate aldolase	-
AM354_RS21780	4554305..4555210	-	906	WP_049234947.1	lipid kinase YegS	-
AM354_RS21785	4555677..4557029	-	1353	WP_033635545.1	tRNA 5-hydroxyuridine modification protein YegQ	-
AM354_RS21790	4557210..4557548	-	339	WP_033648841.1	YegP family protein	-
AM354_RS21795	4557888..4558151	+	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AM354_RS21800	4558155..4558544	+	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
AM354_RS21805	4558552..4559268	-	717	WP_033635542.1	two-component system response regulator BaeR	-
AM354_RS21810	4559268..4560650	-	1383	WP_033635541.1	two-component system sensor histidine kinase BaeS	-
AM354_RS21815	4560647..4562077	-	1431	WP_049213353.1	multidrug transporter subunit MdtD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T95488 WP_041036282.1 NZ_CP026702:4558155-4558544 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T95488 NZ_CP026702:4558155-4558544 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAAGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT95488 WP_004941563.1 NZ_CP026702:4557888-4558151 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT95488 NZ_CP026702:4557888-4558151 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2