Detailed information of TA system TA095486

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4114792..4115461
• Replicon: chromosome
• Accession: NZ_CP026702
• Organism: Serratia marcescens strain AR_0027

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: AM354_RS19605
• Protein ID: WP_033649453.1
• Coordinates: 4115039..4115461 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: AM354_RS19600
• Protein ID: WP_004931679.1
• Coordinates: 4114792..4115058 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM354_RS19575	4110368..4111294	+	927	WP_033635835.1	ribokinase	-
AM354_RS19580	4111326..4111934	-	609	WP_025304127.1	HD domain-containing protein	-
AM354_RS19585	4112118..4112792	+	675	WP_033654067.1	hemolysin III family protein	-
AM354_RS19590	4112943..4113440	+	498	WP_049232293.1	DUF2165 domain-containing protein	-
AM354_RS19595	4113479..4114471	-	993	WP_049232290.1	tRNA-modifying protein YgfZ	-
AM354_RS19600	4114792..4115058	+	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
AM354_RS19605	4115039..4115461	+	423	WP_033649453.1	protein YgfX	Toxin
AM354_RS19610	4115461..4116156	+	696	WP_049232287.1	two-component system response regulator CreB	-
AM354_RS19615	4116153..4117571	+	1419	WP_049232286.1	two-component system sensor histidine kinase CreC	-
AM354_RS19620	4117652..4119016	+	1365	WP_049232284.1	cell envelope integrity protein CreD	-
AM354_RS19625	4119054..4119572	-	519	WP_033635825.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T95486 WP_033649453.1 NZ_CP026702:4115039-4115461 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T95486 NZ_CP026702:4115039-4115461 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT95486 WP_004931679.1 NZ_CP026702:4114792-4115058 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT95486 NZ_CP026702:4114792-4115058 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75