Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2906996..2907597 Replicon chromosome
Accession NZ_CP026702
Organism Serratia marcescens strain AR_0027

Toxin (Protein)


Gene name vapC Uniprot ID A0A2V4FS51
Locus tag AM354_RS13805 Protein ID WP_033649548.1
Coordinates 2907217..2907597 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag AM354_RS13800 Protein ID WP_004933932.1
Coordinates 2906996..2907217 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM354_RS13785 2902144..2903121 + 978 WP_016929588.1 glyoxylate/hydroxypyruvate reductase GhrB -
AM354_RS26570 2903123..2903275 - 153 WP_019455508.1 hypothetical protein -
AM354_RS13790 2903472..2905535 + 2064 WP_049235250.1 alpha-amylase -
AM354_RS13795 2905671..2906921 + 1251 WP_004933935.1 valine--pyruvate transaminase -
AM354_RS13800 2906996..2907217 + 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
AM354_RS13805 2907217..2907597 + 381 WP_033649548.1 type II toxin-antitoxin system VapC family toxin Toxin
AM354_RS13810 2907608..2909266 - 1659 WP_049235249.1 putative transporter -
AM354_RS13815 2909433..2909861 - 429 WP_004933922.1 heat shock chaperone IbpB -
AM354_RS13820 2909962..2910375 - 414 WP_047569943.1 heat shock chaperone IbpA -
AM354_RS13825 2910686..2911033 + 348 WP_033636538.1 YceK/YidQ family lipoprotein -
AM354_RS13830 2911064..2912344 - 1281 WP_047569945.1 DUF3748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14171.50 Da        Isoelectric Point: 7.3170

>T95484 WP_033649548.1 NZ_CP026702:2907217-2907597 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIVWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T95484 NZ_CP026702:2907217-2907597 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTGTCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT95484 WP_004933932.1 NZ_CP026702:2906996-2907217 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT95484 NZ_CP026702:2906996-2907217 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FS51

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References