Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2866093..2866628 Replicon chromosome
Accession NZ_CP026702
Organism Serratia marcescens strain AR_0027

Toxin (Protein)


Gene name relE Uniprot ID A0A5C7D971
Locus tag AM354_RS13625 Protein ID WP_033636570.1
Coordinates 2866093..2866368 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D6BJ42
Locus tag AM354_RS13630 Protein ID WP_047569919.1
Coordinates 2866368..2866628 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM354_RS13605 2861913..2862905 - 993 WP_049235503.1 acyltransferase -
AM354_RS13610 2863123..2864370 + 1248 WP_033638635.1 MFS transporter -
AM354_RS13615 2864422..2865048 - 627 WP_049235504.1 LysE family translocator -
AM354_RS13620 2865170..2866081 + 912 WP_033636572.1 LysR family transcriptional regulator -
AM354_RS13625 2866093..2866368 - 276 WP_033636570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM354_RS13630 2866368..2866628 - 261 WP_047569919.1 ribbon-helix-helix domain-containing protein Antitoxin
AM354_RS13635 2866711..2868552 - 1842 WP_049235505.1 selenocysteine-specific translation elongation factor -
AM354_RS13640 2868549..2869943 - 1395 WP_033649528.1 L-seryl-tRNA(Sec) selenium transferase -
AM354_RS13645 2870013..2870618 - 606 WP_033636563.1 glutathione S-transferase -
AM354_RS13650 2870659..2871309 - 651 WP_033636562.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2857734..2866628 8894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10578.32 Da        Isoelectric Point: 10.3377

>T95483 WP_033636570.1 NZ_CP026702:c2866368-2866093 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T95483 NZ_CP026702:c2866368-2866093 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9683.98 Da        Isoelectric Point: 4.5084

>AT95483 WP_047569919.1 NZ_CP026702:c2866628-2866368 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT95483 NZ_CP026702:c2866628-2866368 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D971

Antitoxin

Source ID Structure
AlphaFold DB A0A7D6BJ42

References