Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2752558..2753030 Replicon chromosome
Accession NZ_CP026702
Organism Serratia marcescens strain AR_0027

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5XNM9
Locus tag AM354_RS13110 Protein ID WP_049234387.1
Coordinates 2752558..2752833 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5XL40
Locus tag AM354_RS13115 Protein ID WP_049234388.1
Coordinates 2752833..2753030 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM354_RS13095 2747602..2747979 - 378 WP_038874139.1 AprI/Inh family metalloprotease inhibitor -
AM354_RS13100 2748035..2749498 - 1464 WP_049234383.1 serralysin family metalloprotease -
AM354_RS13105 2750180..2752498 + 2319 WP_049234385.1 zinc/cadmium/mercury/lead-transporting ATPase -
AM354_RS13110 2752558..2752833 - 276 WP_049234387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM354_RS13115 2752833..2753030 - 198 WP_049234388.1 hypothetical protein Antitoxin
AM354_RS13120 2753092..2753337 - 246 WP_025304890.1 sulfurtransferase TusA -
AM354_RS13125 2753558..2754217 + 660 WP_033636672.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
AM354_RS13130 2754259..2754693 + 435 WP_049234390.1 GNAT family N-acetyltransferase -
AM354_RS13135 2754774..2755337 + 564 WP_033636670.1 DcrB family lipoprotein -
AM354_RS13140 2755373..2756572 - 1200 WP_049234392.1 anaerobic glycerol-3-phosphate dehydrogenase subunit C -
AM354_RS13145 2756569..2757837 - 1269 WP_049234394.1 glycerol-3-phosphate dehydrogenase subunit GlpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10680.59 Da        Isoelectric Point: 11.2806

>T95482 WP_049234387.1 NZ_CP026702:c2752833-2752558 [Serratia marcescens]
MLNIEWTRAARQDLAEIVGFIANDNPLAARKMKVLIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Download         Length: 276 bp

>T95482 NZ_CP026702:c2752833-2752558 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGCCGCACGTCAGGATCTGGCGGAGATTGTGGGATTCATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGTTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTACATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7384.42 Da        Isoelectric Point: 4.2694

>AT95482 WP_049234388.1 NZ_CP026702:c2753030-2752833 [Serratia marcescens]
MSILLLPTVANMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Download         Length: 198 bp

>AT95482 NZ_CP026702:c2753030-2752833 [Serratia marcescens]
ATGAGTATTTTACTACTGCCTACGGTTGCCAATATGGAAAATGAGGAACGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCGCGGCCCGGCATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5XNM9

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5XL40

References