95465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3131846..3132485 Replicon chromosome
Accession NZ_CP026697
Organism Citrobacter koseri strain AR_0025

Toxin (Protein)


Gene name hicA Uniprot ID A0A381H3Z1
Locus tag AM352_RS15120 Protein ID WP_071818852.1
Coordinates 3131846..3132022 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AM352_RS15125 Protein ID WP_146209171.1
Coordinates 3132069..3132485 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM352_RS15100 3126937..3127812 + 876 WP_012132344.1 AraC family transcriptional regulator -
AM352_RS15105 3127789..3128955 - 1167 WP_104868640.1 benzoate/H(+) symporter BenE family transporter -
AM352_RS15110 3129048..3129584 + 537 WP_104868641.1 XRE family transcriptional regulator -
AM352_RS15115 3129663..3131624 + 1962 WP_104869133.1 U32 family peptidase -
AM352_RS15120 3131846..3132022 + 177 WP_071818852.1 type II toxin-antitoxin system HicA family toxin Toxin
AM352_RS15125 3132069..3132485 + 417 WP_146209171.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AM352_RS15130 3132536..3133945 + 1410 WP_104868643.1 PLP-dependent aminotransferase family protein -
AM352_RS15135 3134266..3135690 + 1425 WP_104868644.1 aminobutyraldehyde dehydrogenase -
AM352_RS15140 3135789..3135884 - 96 WP_071818853.1 stress response membrane protein YncL -
AM352_RS15145 3136076..3136249 + 174 WP_047464087.1 GhoT/OrtT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6810.81 Da        Isoelectric Point: 10.8122

>T95465 WP_071818852.1 NZ_CP026697:3131846-3132022 [Citrobacter koseri]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQLGLN

Download         Length: 177 bp

>T95465 NZ_CP026697:3131846-3132022 [Citrobacter koseri]
GTGAAGCAGAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAACGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCTTGGTTTGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15312.59 Da        Isoelectric Point: 4.5129

>AT95465 WP_146209171.1 NZ_CP026697:3132069-3132485 [Citrobacter koseri]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDAADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT95465 NZ_CP026697:3132069-3132485 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAGTCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGCAGCTGATGATTATGTGGAGATTCCTCTAAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTAAAACACGCAACGAAAATCGATGCTGTGCAGATTGCGGCCAGAGCATTGGGCAAAGAGTTAT
CGCTGACTATGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381H3Z1

Antitoxin

Source ID Structure

References