95455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1698321..1698975 Replicon chromosome
Accession NZ_CP026697
Organism Citrobacter koseri strain AR_0025

Toxin (Protein)


Gene name cptA Uniprot ID A0A078LNB4
Locus tag AM352_RS08265 Protein ID WP_024130921.1
Coordinates 1698568..1698975 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A078LG12
Locus tag AM352_RS08260 Protein ID WP_024130922.1
Coordinates 1698321..1698587 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM352_RS08230 1693462..1694895 - 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -
AM352_RS08235 1695016..1695744 - 729 WP_012135006.1 MurR/RpiR family transcriptional regulator -
AM352_RS08240 1695797..1696108 + 312 WP_047461422.1 N(4)-acetylcytidine aminohydrolase -
AM352_RS08245 1696270..1696929 + 660 WP_012135004.1 hemolysin III family protein -
AM352_RS08250 1697084..1698064 - 981 WP_104868221.1 tRNA-modifying protein YgfZ -
AM352_RS08260 1698321..1698587 + 267 WP_024130922.1 FAD assembly factor SdhE Antitoxin
AM352_RS08265 1698568..1698975 + 408 WP_024130921.1 protein YgfX Toxin
AM352_RS08270 1699073..1699597 - 525 WP_012134999.1 flavodoxin FldB -
AM352_RS08275 1699701..1700597 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
AM352_RS08280 1700621..1701331 + 711 WP_104868222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM352_RS08285 1701337..1703070 + 1734 WP_049008966.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15888.77 Da        Isoelectric Point: 11.2845

>T95455 WP_024130921.1 NZ_CP026697:1698568-1698975 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQATQG

Download         Length: 408 bp

>T95455 NZ_CP026697:1698568-1698975 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGCCCGCCCTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCACTTGTGGCTGGCGGCGGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10476.00 Da        Isoelectric Point: 4.8836

>AT95455 WP_024130922.1 NZ_CP026697:1698321-1698587 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT95455 NZ_CP026697:1698321-1698587 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A078LNB4

Antitoxin

Source ID Structure
AlphaFold DB A0A078LG12

References