Detailed information of TA system TA095454

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 923428..924115
• Replicon: chromosome
• Accession: NZ_CP026697
• Organism: Citrobacter koseri strain AR_0025

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AM352_RS04360
• Protein ID: WP_104867992.1
• Coordinates: 923428..923748 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AM352_RS04365
• Protein ID: WP_104867993.1
• Coordinates: 923783..924115 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM352_RS04340	918791..919693	-	903	WP_024131066.1	carboxylate/amino acid/amine transporter	-
AM352_RS04345	919787..920875	-	1089	WP_012135794.1	AAA family ATPase	-
AM352_RS04350	921002..922009	-	1008	WP_012135793.1	zinc-binding alcohol dehydrogenase family protein	-
AM352_RS04355	922121..923029	+	909	WP_012135792.1	LysR family transcriptional regulator	-
AM352_RS04360	923428..923748	-	321	WP_104867992.1	TA system toxin CbtA family protein	Toxin
AM352_RS04365	923783..924115	-	333	WP_104867993.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AM352_RS04370	924128..924598	-	471	WP_104867994.1	DNA repair protein RadC	-
AM352_RS04375	924668..925489	-	822	WP_104867995.1	DUF945 domain-containing protein	-
AM352_RS04385	926105..926944	-	840	WP_104867997.1	hypothetical protein	-
AM352_RS04390	927004..927438	-	435	WP_104867998.1	hypothetical protein	-
AM352_RS04395	927795..929114	-	1320	WP_158661210.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	917360..939141	21781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-104)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12144.74 Da
• Isoelectric Point: 5.0356

>T95454 WP_104867992.1 NZ_CP026697:c923748-923428 [Citrobacter koseri]
MQISTAPNIVPVSSRPSPVKVWQQLLTYLLEHHYGLTINDTPFSDDTAILEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Nucleotide

• Length: 321 bp

>T95454 NZ_CP026697:c923748-923428 [Citrobacter koseri]
ATGCAAATTTCAACTGCTCCGAACATCGTGCCGGTTTCGTCACGACCATCTCCTGTCAAAGTATGGCAACAATTATTAAC
ATACCTTTTAGAGCATCATTACGGCCTGACGATCAACGACACACCGTTCAGTGACGATACGGCGATTCTGGAACACATAG
AGGCGGGAGTGAATCTTACCGATGCCGTTAACTTTCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12482.21 Da
• Isoelectric Point: 7.3203

>AT95454 WP_104867993.1 NZ_CP026697:c924115-923783 [Citrobacter koseri]
MSLTPAHEWGLKSDIVPRFGARLIQEGNRLHYLADRAGLKGNFTPEQLQDLERSFPAITEKLENLLRTGELNPRQQHQVV
VHLAGFTCIADTCGSWGYVYITIYPQPGYR

Nucleotide

• Length: 333 bp

>AT95454 NZ_CP026697:c924115-923783 [Citrobacter koseri]
ATGTCATTAACACCAGCCCATGAATGGGGGCTAAAAAGCGATATTGTTCCACGTTTTGGTGCCAGATTAATTCAGGAAGG
CAACAGGCTGCATTACCTGGCAGACAGGGCCGGGTTGAAGGGGAACTTTACCCCTGAGCAGCTGCAGGATTTAGAGCGAT
CTTTCCCTGCGATCACAGAAAAACTTGAAAATCTGCTGCGTACTGGCGAGCTAAACCCGCGCCAGCAACACCAGGTGGTA
GTTCACCTTGCGGGGTTTACCTGCATAGCAGATACCTGTGGTAGCTGGGGCTACGTTTACATCACTATTTATCCTCAGCC
TGGCTACAGGTAA