Detailed information of TA system TA095452

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 174292..174880
• Replicon: chromosome
• Accession: NZ_CP026697
• Organism: Citrobacter koseri strain AR_0025

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: AM352_RS00825
• Protein ID: WP_104867819.1
• Coordinates: 174292..174519 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: AM352_RS00830
• Protein ID: WP_104867820.1
• Coordinates: 174539..174880 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM352_RS00820	170912..173674	-	2763	WP_024152501.1	hypothetical protein	-
AM352_RS00825	174292..174519	-	228	WP_104867819.1	TA system toxin CbtA family protein	Toxin
AM352_RS00830	174539..174880	-	342	WP_104867820.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AM352_RS00835	174891..175433	-	543	WP_104867821.1	DNA repair protein RadC	-
AM352_RS00840	175446..175886	-	441	WP_104867822.1	antirestriction protein	-
AM352_RS00845	175917..176738	-	822	WP_104867823.1	DUF945 domain-containing protein	-
AM352_RS00850	176859..177332	-	474	WP_187305244.1	hypothetical protein	-
AM352_RS00855	177433..177897	-	465	WP_058587134.1	hypothetical protein	-
AM352_RS00860	178207..179082	-	876	WP_049033289.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-52)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8542.17 Da
• Isoelectric Point: 7.8603

>T95452 WP_104867819.1 NZ_CP026697:c174519-174292 [Citrobacter koseri]
MKFLPATTPQAATLCLSPLAVWQMLLKRLLEQHYSLMLNDTSFSDEPLYRNMLMLVLVSDAFQLVHTSKVCRLSA

Nucleotide

• Length: 228 bp

>T95452 NZ_CP026697:c174519-174292 [Citrobacter koseri]
ATGAAATTTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCTTGGCAGTCTGGCAAATGCTGCTTAA
ACGTCTGCTGGAACAGCACTACAGTCTGATGCTAAACGACACATCTTTCAGTGATGAGCCGTTATATAGGAACATGTTGA
TGCTAGTACTCGTCTCTGATGCTTTTCAGTTAGTTCACACTTCTAAAGTTTGTCGGCTATCAGCATAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12801.44 Da
• Isoelectric Point: 6.3148

>AT95452 WP_104867820.1 NZ_CP026697:c174880-174539 [Citrobacter koseri]
MKSTDSENDSFLKWGLNCNVTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFIRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT95452 NZ_CP026697:c174880-174539 [Citrobacter koseri]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATTGTAATGTGACACCTTGCTTTGGTGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGATCGGGCCTGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCATACGTTTTATCCGCCAAATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACAGCGTCACCCTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACATCGC
CGTTTACCCCACTCATCGTTAG