Detailed information of TA system TA095449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1009470..1010178
• Replicon: chromosome
• Accession: NZ_CP026692
• Organism: Nostoc sp. 'Lobaria pulmonaria (5183) cyanobiont' strain 5183

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: NLP_RS04280
• Protein ID: WP_104905299.1
• Coordinates: 1009801..1010178 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: NLP_RS04275
• Protein ID: WP_104905298.1
• Coordinates: 1009470..1009796 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLP_RS04260	1005215..1007119	+	1905	WP_104905296.1	GTPase family protein	-
NLP_RS04265	1007495..1009174	+	1680	WP_158680278.1	response regulator	-
NLP_RS04270	1009211..1009360	-	150	Protein_848	DUF29 family protein	-
NLP_RS04275	1009470..1009796	-	327	WP_104905298.1	helix-turn-helix domain-containing protein	Antitoxin
NLP_RS04280	1009801..1010178	-	378	WP_104905299.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NLP_RS32765	1010200..1010406	-	207	WP_158680279.1	hypothetical protein	-
NLP_RS04285	1010485..1011594	-	1110	WP_104905300.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
NLP_RS04290	1011999..1013282	+	1284	WP_104905301.1	valine--pyruvate transaminase	-
NLP_RS04295	1013297..1014034	+	738	WP_104905302.1	ribosome maturation factor RimM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-82)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13988.73 Da
• Isoelectric Point: 6.6463

>T95449 WP_104905299.1 NZ_CP026692:c1010178-1009801 [Nostoc sp. 'Lobaria pulmonaria (5183) cyanobiont']
MSETHQKAFKWIGSALDDLKDFPEDVQDVMGYALDVAQHGGKHPDAKPLRGFRGGGVLEVVDDFDGDTYRAVYTVKFAGF
VYLLHAFQKKSKHGIATSQQDIDLVKKRLKAAQEDYSEQAAKQKE

Nucleotide

• Length: 378 bp

>T95449 NZ_CP026692:c1010178-1009801 [Nostoc sp. 'Lobaria pulmonaria (5183) cyanobiont']
ATGAGCGAAACGCACCAAAAAGCTTTCAAATGGATTGGAAGCGCTTTAGATGACTTAAAGGATTTCCCTGAAGACGTACA
AGACGTAATGGGTTACGCCCTTGATGTAGCACAACATGGGGGTAAGCATCCCGATGCAAAACCCCTGCGCGGTTTTAGAG
GAGGCGGGGTTTTAGAGGTTGTAGATGATTTTGATGGAGATACATACCGAGCAGTGTACACTGTAAAATTTGCGGGGTTT
GTCTACTTATTACACGCGTTTCAAAAGAAGTCAAAACATGGTATTGCTACATCACAACAAGATATAGATTTAGTAAAAAA
GAGGTTAAAAGCCGCTCAGGAAGACTATTCGGAACAAGCTGCTAAACAAAAGGAGTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12090.86 Da
• Isoelectric Point: 9.0735

>AT95449 WP_104905298.1 NZ_CP026692:c1009796-1009470 [Nostoc sp. 'Lobaria pulmonaria (5183) cyanobiont']
VTKENSVYTSSGNVFADLGLPNSEERLVKAELARKISEAITFRKLTQVQAAELLGIDQPKISALVRGRLSGFSIDRLFQF
LNDLDNDVEIVIKRKPEDRKQARTTVVC

Nucleotide

• Length: 327 bp

>AT95449 NZ_CP026692:c1009796-1009470 [Nostoc sp. 'Lobaria pulmonaria (5183) cyanobiont']
GTGACTAAAGAAAATAGCGTTTATACTAGCAGTGGAAATGTATTTGCTGACTTAGGCTTACCTAATTCTGAAGAAAGATT
AGTGAAAGCTGAACTAGCACGCAAAATCAGTGAAGCAATCACTTTCCGTAAATTAACACAAGTCCAAGCTGCTGAACTTT
TAGGAATTGATCAACCAAAAATTTCAGCATTGGTGAGAGGCAGACTTTCAGGCTTTTCAATTGATAGATTATTTCAATTT
TTGAATGATTTAGATAATGATGTAGAGATTGTCATCAAACGAAAACCTGAAGACCGCAAGCAAGCTCGGACAACAGTTGT
TTGCTAA