Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1716340..1718006 Replicon chromosome
Accession NZ_CP026676
Organism Pseudomonas sp. SWI6

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C4Q28_RS08100 Protein ID WP_104881375.1
Coordinates 1717158..1718006 (-) Length 283 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C4Q28_RS08095 Protein ID WP_027907431.1
Coordinates 1716340..1717152 (-) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4Q28_RS08075 1711551..1713041 - 1491 WP_023381738.1 aldehyde dehydrogenase -
C4Q28_RS08080 1713052..1713855 - 804 WP_023381737.1 aspartate dehydrogenase -
C4Q28_RS08085 1713866..1715548 - 1683 WP_104881374.1 thiamine pyrophosphate-binding protein -
C4Q28_RS08090 1715541..1716338 - 798 WP_023381735.1 SDR family oxidoreductase -
C4Q28_RS08095 1716340..1717152 - 813 WP_027907431.1 IclR family transcriptional regulator Antitoxin
C4Q28_RS08100 1717158..1718006 - 849 WP_104881375.1 alpha/beta hydrolase Toxin
C4Q28_RS08105 1718011..1718550 - 540 WP_023381732.1 cupin domain-containing protein -
C4Q28_RS08110 1718565..1719329 - 765 WP_104882342.1 SDR family oxidoreductase -
C4Q28_RS08115 1719329..1720105 - 777 WP_023381730.1 ABC transporter permease -
C4Q28_RS08120 1720134..1721135 - 1002 WP_023381729.1 ABC transporter substrate-binding protein -
C4Q28_RS08125 1721167..1722012 - 846 WP_023381728.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(38-265)

Antitoxin

Transcription regulator IclR, N-terminal

(16-65)


Sequences

Toxin        


Download         Length: 283 a.a.        Molecular weight: 29570.05 Da        Isoelectric Point: 6.8808

>T95433 WP_104881375.1 NZ_CP026676:c1718006-1717158 [Pseudomonas sp. SWI6]
MIPLMPTPSLLDQRFAERLLRLDGGQLAVRQAGDGDAVVLLHGIGSGAASWLHVAMGLSERARVLAWDAPGYGQSSPLPM
AAPCARDYAGRLLQALDTLGVERCVLVGHSLGALTASAFAQACPERVNRLVLISPARGYGAVPDQGRAVRAERLHNLGQL
GIERMARERSARLLSANASAEAQAWVHWNMARLKPHGYRQAIELLCGDDLLRYAPLAVACQVHCGSADGITLPEDCAALA
AALAAPFDLIAGAGHACAIEQPDTVTGLLARALDASLTGSVL

Download         Length: 849 bp

>T95433 NZ_CP026676:c1718006-1717158 [Pseudomonas sp. SWI6]
ATGATACCGCTCATGCCCACCCCCTCCCTGCTCGATCAGCGCTTCGCCGAACGTCTGCTGCGCCTGGATGGCGGCCAGTT
GGCCGTGCGCCAAGCCGGCGACGGTGACGCCGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCAGCTGGCTGCACG
TGGCCATGGGTTTGAGCGAGCGGGCTCGGGTACTGGCCTGGGACGCACCGGGCTATGGCCAGTCCTCGCCTTTGCCGATG
GCTGCGCCCTGCGCACGGGACTATGCCGGACGCCTGCTGCAGGCACTGGATACCTTGGGTGTCGAGCGTTGCGTGCTGGT
CGGCCACTCCCTCGGGGCACTGACCGCCAGCGCCTTCGCCCAGGCCTGCCCTGAGCGCGTCAACCGCCTGGTACTGATCA
GCCCGGCGCGCGGATACGGCGCTGTGCCGGATCAAGGCCGGGCGGTGCGCGCCGAGCGCCTGCACAACCTTGGGCAACTG
GGCATCGAACGCATGGCCCGCGAGCGCAGCGCACGGTTGCTGTCGGCAAACGCCAGCGCCGAGGCGCAGGCCTGGGTGCA
CTGGAACATGGCGCGGCTCAAGCCCCATGGCTACCGCCAAGCCATCGAATTGCTGTGCGGCGACGACCTGCTGCGCTACG
CGCCCCTGGCGGTTGCGTGCCAGGTGCACTGCGGCAGCGCAGACGGCATCACCCTGCCCGAGGACTGCGCGGCACTCGCC
GCTGCACTGGCCGCGCCCTTCGACCTGATTGCCGGCGCCGGCCATGCCTGCGCCATCGAACAACCTGACACGGTGACGGG
CCTGCTGGCCCGCGCCCTCGACGCCTCTCTGACAGGTAGCGTGCTATGA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29767.26 Da        Isoelectric Point: 6.6423

>AT95433 WP_027907431.1 NZ_CP026676:c1717152-1716340 [Pseudomonas sp. SWI6]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLAELR
ELYPEEHLEQYSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDASGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYRPGSGHVTALMRD

Download         Length: 813 bp

>AT95433 NZ_CP026676:c1717152-1716340 [Pseudomonas sp. SWI6]
ATGGATCCGTTGAAGGAAAACCAGGACAAGTACATCGTCCCGGGCCTGGAGCGCGGCCTGCTGTTGCTGTGCGAATTCAG
CCGGCAGAACCGCACCCTGACCGCCCCCGAACTGGCCCGGCGTCTGTCGCTGCCACGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGGTTCGTCACCCGCAGCGGCAACGAATACCGCCTCGGCATGTCGGTGCTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAGCTTGGCCAGCCGTTGCTGGCGCGGCTGTGCGATCACCTCAACTACCCCAG
CAATCTGGTGGTACGCGATGGCCGCTCAATTGTCTACGTGGCCAAGGTCTCGCCGCCTTCGGTGTTCTCCAGCGCGGTCA
CCGTGGGTACCCGCCTGCCAGCCCATGCCACCGTGCTCGGACGTATCCTGCTGGCCGACCTGAGCCTGGCCGAACTGCGT
GAGCTGTACCCCGAAGAGCATCTGGAGCAGTACTCGCCGTGCACGCCCAAAACCGTGCTGGAGCTGTTCGACCTGGTGCA
GGCCGACCGCCTGCGTGGCTATGTCAGCGGCGAGGGCTTCTTCGAGTCGACCATCTCCACGGTGGCGGCGCCGGTGCGCG
ATGCCAGCGGCCAGGTAGTCGCAGCCCTCGGCCTGACCATCCCCACGGTGCAGATCGGCCACGTCAACTTCGACAACCTG
CTCGGCCAGGTGCGTGGCAGCGCCGACGAACTGTCGCGCCTGCTCAACTACCGACCCGGCAGTGGCCATGTCACCGCGTT
GATGAGGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References