Detailed information of TA system TA095431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 4642574..4643457
• Replicon: chromosome
• Accession: NZ_CP026675
• Organism: Pseudomonas sp. SWI36

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q88K57
• Locus tag: C4Q27_RS22160
• Protein ID: WP_003250527.1
• Coordinates: 4643020..4643457 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: I7C3Q7
• Locus tag: C4Q27_RS22155
• Protein ID: WP_003250525.1
• Coordinates: 4642574..4643023 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4Q27_RS22130	4637997..4639196	+	1200	WP_104887379.1	sugar transporter	-
C4Q27_RS22135	4639236..4639820	-	585	WP_064492455.1	LysE family transporter	-
C4Q27_RS22140	4639872..4640702	-	831	WP_064492456.1	AraC family transcriptional regulator	-
C4Q27_RS22145	4640751..4641674	-	924	WP_010953383.1	LysR family transcriptional regulator	-
C4Q27_RS22150	4641778..4642431	+	654	WP_014591578.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
C4Q27_RS22155	4642574..4643023	+	450	WP_003250525.1	DUF2384 domain-containing protein	Antitoxin
C4Q27_RS22160	4643020..4643457	+	438	WP_003250527.1	RES family NAD+ phosphorylase	Toxin
C4Q27_RS22165	4643492..4644646	-	1155	WP_064492465.1	aminotransferase class V-fold PLP-dependent enzyme	-
C4Q27_RS22170	4644841..4645767	-	927	WP_010953387.1	LysR family transcriptional regulator	-
C4Q27_RS22175	4645908..4647137	+	1230	WP_104887380.1	acyl-CoA dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-138)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (33-91)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15990.29 Da
• Isoelectric Point: 5.6007

>T95431 WP_003250527.1 NZ_CP026675:4643020-4643457 [Pseudomonas sp. SWI36]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAQPELTRTLGNRFLDDCSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Nucleotide

• Length: 438 bp

>T95431 NZ_CP026675:4643020-4643457 [Pseudomonas sp. SWI36]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCGGTGGTGTATGCCGCCACCAGTCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCTACCACCATGCGCTTGCTGCGCATCGAACTGCCTGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCCCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACTGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16956.46 Da
• Isoelectric Point: 5.7258

>AT95431 WP_003250525.1 NZ_CP026675:4642574-4643023 [Pseudomonas sp. SWI36]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Nucleotide

• Length: 450 bp

>AT95431 NZ_CP026675:4642574-4643023 [Pseudomonas sp. SWI36]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTATCACGAGTACCGGGCGCGCCTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGCGACTTCGAAATTCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTGAAGCTGACCGAGCGCGGTG
TGCTCACCCCGGTGGAGCGCGACCAGATCATTCCGCTGCGCACCCTCAAATCCCGTATCGAGCGTGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTCGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAACGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CTCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA

Structures

Toxin

• PDB: 6GW6

Antitoxin

• AlphaFold DB: I7C3Q7