Detailed information of TA system TA095426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 428326..429365
• Replicon: chromosome
• Accession: NZ_CP026675
• Organism: Pseudomonas sp. SWI36

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: C4Q27_RS02255
• Protein ID: WP_104886398.1
• Coordinates: 428790..429365 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A2L1I993
• Locus tag: C4Q27_RS02250
• Protein ID: WP_064493160.1
• Coordinates: 428326..428793 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4Q27_RS02235	424478..425551	+	1074	WP_010954918.1	microcin C ABC transporter permease YejB	-
C4Q27_RS02240	425553..426572	+	1020	WP_003251467.1	ABC transporter permease	-
C4Q27_RS02245	426574..428178	+	1605	WP_104886397.1	ABC transporter ATP-binding protein	-
C4Q27_RS02250	428326..428793	+	468	WP_064493160.1	helix-turn-helix domain-containing protein	Antitoxin
C4Q27_RS02255	428790..429365	+	576	WP_104886398.1	PIN domain-containing protein	Toxin
C4Q27_RS02260	429579..432509	+	2931	WP_064493158.1	aminotransferase	-
C4Q27_RS02265	432513..433736	-	1224	WP_104886399.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21656.90 Da
• Isoelectric Point: 5.5710

>T95426 WP_104886398.1 NZ_CP026675:428790-429365 [Pseudomonas sp. SWI36]
MKHSPFTAIYDANVLYPAPLRDFLMNLALTGIYRARWSASIHDEWKRNLLLNRPDLTPEHLDRTSSLMDAAVPDALVTDY
DSLVEGLDLPDRDDRHVLAAAIKCNASVIVTFNLKDFPKAVLGAFDIEPLHPDDFIADLWDLDKAAVLEAAQRQRISLKN
PPHSVQQYLDRLLQQKLPETVKLLSAFKFLL

Nucleotide

• Length: 576 bp

>T95426 NZ_CP026675:428790-429365 [Pseudomonas sp. SWI36]
ATGAAGCACTCGCCCTTCACGGCCATATACGACGCGAATGTACTTTACCCTGCTCCACTGCGTGATTTCCTGATGAACCT
AGCGCTGACGGGCATCTACCGGGCACGTTGGTCAGCGAGCATTCATGACGAGTGGAAGCGCAATCTGCTACTCAACCGGC
CTGACCTCACGCCTGAACATTTGGATCGCACGTCATCGCTGATGGATGCTGCGGTGCCTGATGCACTCGTCACTGACTAC
GATTCACTGGTCGAAGGGCTGGACTTGCCAGATAGGGATGATCGACATGTTCTCGCAGCTGCAATCAAGTGCAACGCTTC
GGTTATCGTCACCTTCAATTTGAAGGATTTTCCCAAGGCGGTTCTCGGTGCCTTCGATATTGAACCCTTGCATCCGGACG
ACTTCATCGCTGACCTTTGGGACCTGGACAAGGCAGCAGTCCTCGAAGCTGCCCAGCGGCAGCGAATATCGCTGAAGAAC
CCACCGCACAGCGTACAGCAGTATCTCGACAGGCTGCTTCAGCAGAAGCTTCCCGAGACAGTGAAACTGCTTTCGGCATT
CAAGTTCCTCCTCTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17130.57 Da
• Isoelectric Point: 6.3403

>AT95426 WP_064493160.1 NZ_CP026675:428326-428793 [Pseudomonas sp. SWI36]
MTTANLSSHVLPDEKEIAVAVESSRTLAAFLSTKSDTQRIELLNEENQRQVVEVPTFALRLFGEILSELALGNSVKVVPI
HAELTTQEAADLLNVSRPHLVKLLDEAVIPHTKTGRHRRVKFSDLVAYKDKRDGVSRAAMDALAAQAQELKMGYE

Nucleotide

• Length: 468 bp

>AT95426 NZ_CP026675:428326-428793 [Pseudomonas sp. SWI36]
ATGACCACCGCCAACCTCTCTAGCCATGTGCTTCCTGACGAGAAAGAAATTGCCGTGGCAGTCGAGTCAAGCCGCACGCT
GGCAGCGTTCCTCTCGACAAAATCAGATACCCAACGGATCGAACTGCTCAACGAGGAAAATCAGCGCCAGGTTGTTGAAG
TACCTACTTTCGCCCTACGCCTATTCGGCGAGATTCTCAGCGAACTGGCCCTGGGTAACTCAGTCAAAGTCGTTCCAATC
CACGCCGAACTGACTACCCAGGAAGCAGCAGACCTGCTTAACGTCTCCCGGCCGCACTTGGTAAAGCTGCTCGACGAAGC
GGTGATTCCGCACACCAAGACAGGCCGCCATCGTCGTGTCAAATTCTCCGACCTGGTTGCCTACAAGGACAAACGTGATG
GGGTGAGCCGCGCTGCGATGGATGCGCTGGCAGCCCAAGCTCAGGAATTGAAGATGGGGTACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2L1I993