Detailed information of TA system TA095425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 165581..166234
• Replicon: chromosome
• Accession: NZ_CP026675
• Organism: Pseudomonas sp. SWI36

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C4Q27_RS00965
• Protein ID: WP_104886297.1
• Coordinates: 165581..165778 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4Q27_RS00970
• Protein ID: WP_104886298.1
• Coordinates: 165809..166234 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4Q27_RS00935	161818..163305	-	1488	WP_104886291.1	terminase	-
C4Q27_RS00940	163365..163907	-	543	WP_104886292.1	hypothetical protein	-
C4Q27_RS00945	163964..164152	-	189	WP_104886293.1	DUF2158 domain-containing protein	-
C4Q27_RS00950	164223..164414	-	192	WP_104886294.1	hypothetical protein	-
C4Q27_RS00955	164475..164945	-	471	WP_104886295.1	DUF1311 domain-containing protein	-
C4Q27_RS00960	165075..165410	-	336	WP_104886296.1	phage holin, lambda family	-
C4Q27_RS00965	165581..165778	+	198	WP_104886297.1	mRNA interferase	Toxin
C4Q27_RS00970	165809..166234	+	426	WP_104886298.1	transcriptional regulator	Antitoxin
C4Q27_RS00975	166342..167487	-	1146	WP_104886299.1	hypothetical protein	-
C4Q27_RS00980	167601..167768	-	168	WP_104886300.1	Com family DNA-binding transcriptional regulator	-
C4Q27_RS00985	168072..168662	-	591	WP_104886301.1	hypothetical protein	-
C4Q27_RS00990	168778..169383	-	606	WP_104886302.1	recombination protein NinG	-
C4Q27_RS29215	169580..169741	-	162	WP_158666112.1	hypothetical protein	-
C4Q27_RS01000	169738..170207	-	470	Protein_190	hypothetical protein	-
C4Q27_RS01005	170200..170415	-	216	WP_104886304.1	hypothetical protein	-
C4Q27_RS01010	170412..171137	-	726	WP_104886305.1	Replication protein P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	127093..190619	63526

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7358.57 Da
• Isoelectric Point: 10.6925

>T95425 WP_104886297.1 NZ_CP026675:165581-165778 [Pseudomonas sp. SWI36]
MKFSEFRRWLKAQGVAFEAGKEATSKSPPQTAKAIFADHGCKEMPEPTRKAFIKQLGLKEPLRHT

Nucleotide

• Length: 198 bp

>T95425 NZ_CP026675:165581-165778 [Pseudomonas sp. SWI36]
ATGAAGTTCAGCGAGTTCAGACGATGGTTGAAGGCCCAAGGGGTGGCCTTCGAAGCAGGCAAGGAAGCCACTTCAAAGTC
ACCGCCCCAAACGGCAAAGGCAATCTTCGCGGATCACGGTTGCAAGGAAATGCCAGAACCGACCCGCAAGGCGTTCATTA
AACAACTAGGGCTCAAAGAGCCCCTTCGCCACACCTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15755.92 Da
• Isoelectric Point: 4.6719

>AT95425 WP_104886298.1 NZ_CP026675:165809-166234 [Pseudomonas sp. SWI36]
MYNYAIRFERDDTPGLAVFCRDLPQFHSYGDNEQHALSEAVDGIETTLSIYVDERRSIPAASEPETGELVVHLPAVTVAK
IVLWNEMMARDMRKADLCRLLGLAQTQGDRLVDFRHTSKMEAMETALAALGKQLVVSVEST

Nucleotide

• Length: 426 bp

>AT95425 NZ_CP026675:165809-166234 [Pseudomonas sp. SWI36]
ATGTACAACTATGCAATCCGCTTTGAGCGCGACGACACACCTGGGCTAGCAGTGTTTTGTCGCGACCTGCCGCAGTTTCA
CAGCTACGGCGATAACGAGCAACACGCGCTAAGCGAAGCGGTGGATGGTATCGAGACGACCCTGTCGATATATGTCGATG
AGCGTCGCTCGATCCCCGCTGCGTCCGAACCTGAGACTGGCGAGTTGGTTGTCCACTTGCCTGCGGTGACCGTGGCGAAG
ATCGTGCTGTGGAACGAAATGATGGCCCGCGATATGCGCAAGGCCGATCTGTGCCGCCTGCTTGGCTTGGCGCAGACCCA
AGGAGATCGTCTTGTCGACTTCCGGCACACTTCGAAGATGGAGGCAATGGAGACGGCGCTAGCCGCGCTCGGCAAACAAC
TGGTGGTGTCTGTCGAGTCGACTTGA