Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4008650..4010316 Replicon chromosome
Accession NZ_CP026674
Organism Pseudomonas sp. SWI44

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C4Q26_RS18885 Protein ID WP_041925530.1
Coordinates 4009468..4010316 (-) Length 283 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C4Q26_RS18880 Protein ID WP_027907431.1
Coordinates 4008650..4009462 (-) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4Q26_RS18860 4003861..4005351 - 1491 WP_023381738.1 aldehyde dehydrogenase -
C4Q26_RS18865 4005362..4006165 - 804 WP_023381737.1 aspartate dehydrogenase -
C4Q26_RS18870 4006176..4007858 - 1683 WP_023381736.1 thiamine pyrophosphate-binding protein -
C4Q26_RS18875 4007851..4008648 - 798 WP_023381735.1 SDR family oxidoreductase -
C4Q26_RS18880 4008650..4009462 - 813 WP_027907431.1 IclR family transcriptional regulator Antitoxin
C4Q26_RS18885 4009468..4010316 - 849 WP_041925530.1 alpha/beta hydrolase Toxin
C4Q26_RS18890 4010321..4010860 - 540 WP_023381732.1 cupin domain-containing protein -
C4Q26_RS18895 4010875..4011639 - 765 WP_023381731.1 SDR family oxidoreductase -
C4Q26_RS18900 4011639..4012415 - 777 WP_023381730.1 ABC transporter permease -
C4Q26_RS18905 4012444..4013447 - 1004 Protein_3657 ABC transporter substrate-binding protein -
C4Q26_RS18910 4013479..4014324 - 846 WP_023381728.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(38-265)

Antitoxin

Transcription regulator IclR, N-terminal

(16-65)


Sequences

Toxin        


Download         Length: 283 a.a.        Molecular weight: 29568.01 Da        Isoelectric Point: 6.8859

>T95424 WP_041925530.1 NZ_CP026674:c4010316-4009468 [Pseudomonas sp. SWI44]
MIPLMPTPSLLDQRFAERLLRLDGGQLAVRQAGDGDAVVLLHGIGSGAASWLHVAMGLSERARVLAWDAPGYGQSSPLPM
AAPSARDYAGRLLQALDTLGIERCVLVGHSLGALTASAFAQACPERVNRLVLISPARGYGAVPDQGRAVRAERLHNLGQL
GIERMARERSARLLSANASAEAQAWVHWNMARLKPHGYRQAIELLCGDDLLRYAPLAVACQVHCGSADGITLPEDCAALA
AALAAPFDLIAGAGHACAIEQPDTVTGLLARALDASLTGSVL

Download         Length: 849 bp

>T95424 NZ_CP026674:c4010316-4009468 [Pseudomonas sp. SWI44]
ATGATACCGCTCATGCCCACCCCCTCCCTGCTCGATCAGCGCTTCGCCGAACGTCTGCTGCGCCTGGATGGCGGCCAGTT
GGCCGTGCGCCAAGCCGGCGACGGTGACGCCGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCAGCTGGCTGCACG
TGGCCATGGGTTTGAGCGAGCGGGCTCGGGTACTGGCCTGGGACGCACCGGGCTATGGCCAGTCCTCGCCTTTGCCGATG
GCTGCGCCCAGCGCACGGGACTATGCCGGACGCCTGCTGCAGGCACTGGATACCTTGGGTATCGAGCGTTGCGTGCTGGT
CGGCCACTCCCTCGGGGCACTGACCGCCAGCGCCTTCGCCCAGGCCTGCCCTGAGCGCGTCAACCGCCTGGTACTGATCA
GCCCGGCGCGCGGATACGGCGCTGTGCCGGATCAAGGCCGGGCGGTGCGCGCCGAGCGCCTGCACAACCTTGGGCAACTG
GGCATCGAACGCATGGCCCGCGAGCGCAGCGCACGGTTGCTGTCGGCAAACGCCAGCGCCGAGGCGCAGGCCTGGGTGCA
CTGGAACATGGCGCGGCTCAAGCCCCATGGCTACCGCCAAGCCATCGAATTGCTGTGCGGCGACGACCTGCTGCGCTACG
CGCCCCTGGCGGTTGCGTGCCAGGTGCACTGCGGCAGCGCAGACGGCATCACCCTGCCCGAGGACTGCGCGGCACTCGCC
GCTGCACTGGCCGCGCCCTTCGACCTGATTGCCGGCGCCGGCCATGCCTGCGCCATCGAACAACCTGACACGGTGACGGG
CCTGCTGGCCCGCGCCCTCGACGCCTCTCTGACAGGTAGCGTGCTATGA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29767.26 Da        Isoelectric Point: 6.6423

>AT95424 WP_027907431.1 NZ_CP026674:c4009462-4008650 [Pseudomonas sp. SWI44]
MDPLKENQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLSLPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLRLGF
EYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVTVGTRLPAHATVLGRILLADLSLAELR
ELYPEEHLEQYSPCTPKTVLELFDLVQADRLRGYVSGEGFFESTISTVAAPVRDASGQVVAALGLTIPTVQIGHVNFDNL
LGQVRGSADELSRLLNYRPGSGHVTALMRD

Download         Length: 813 bp

>AT95424 NZ_CP026674:c4009462-4008650 [Pseudomonas sp. SWI44]
ATGGATCCGTTGAAGGAAAACCAGGACAAGTACATCGTCCCGGGCCTGGAGCGCGGCCTGCTGTTGCTGTGCGAATTCAG
CCGGCAGAACCGCACCCTGACCGCCCCCGAACTGGCCCGGCGTCTGTCGCTGCCACGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAAACCATGGGGTTCGTCACCCGCAGCGGCAACGAATACCGCCTCGGCATGTCGGTGCTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAGCTTGGCCAGCCGTTGCTGGCGCGGCTGTGCGATCACCTCAACTACCCCAG
CAATCTGGTGGTACGCGATGGCCGCTCGATTGTCTACGTGGCCAAGGTCTCGCCGCCTTCGGTGTTCTCCAGCGCGGTCA
CCGTGGGTACCCGCCTGCCAGCCCATGCCACCGTGCTCGGACGTATCCTGCTGGCCGACCTGAGCCTGGCCGAACTGCGT
GAGCTGTACCCCGAAGAGCATCTGGAGCAGTACTCGCCGTGCACGCCCAAAACCGTGCTGGAGCTGTTCGACCTGGTGCA
GGCCGACCGCCTGCGTGGCTATGTCAGCGGCGAGGGCTTCTTCGAGTCGACCATCTCCACGGTGGCGGCGCCGGTGCGCG
ATGCCAGCGGCCAGGTAGTCGCAGCCCTCGGCCTGACCATCCCCACGGTGCAGATCGGCCACGTCAACTTCGACAACCTG
CTCGGCCAGGTGCGTGGCAGCGCCGACGAACTGTCGCGCCTGCTCAACTACCGACCCGGCAGCGGCCATGTCACCGCGTT
GATGAGGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References