Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2774843..2775371 Replicon chromosome
Accession NZ_CP026674
Organism Pseudomonas sp. SWI44

Toxin (Protein)


Gene name relE Uniprot ID A0A2L1HEZ8
Locus tag C4Q26_RS13015 Protein ID WP_027907232.1
Coordinates 2775072..2775371 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2L1HF13
Locus tag C4Q26_RS13010 Protein ID WP_023382870.1
Coordinates 2774843..2775082 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4Q26_RS12995 2769979..2771355 - 1377 WP_023382873.1 HAMP domain-containing protein -
C4Q26_RS13000 2771348..2772067 - 720 WP_023382872.1 response regulator transcription factor -
C4Q26_RS13005 2772224..2774503 + 2280 WP_104884040.1 TonB-dependent siderophore receptor -
C4Q26_RS13010 2774843..2775082 + 240 WP_023382870.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C4Q26_RS13015 2775072..2775371 + 300 WP_027907232.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4Q26_RS13020 2775493..2776349 + 857 WP_104881095.1 IS5 family transposase -
C4Q26_RS13025 2776903..2777241 + 339 WP_104883144.1 hypothetical protein -
C4Q26_RS13030 2777234..2778319 + 1086 WP_158664888.1 ImmA/IrrE family metallo-endopeptidase -
C4Q26_RS13035 2778320..2779222 - 903 WP_104884041.1 hypothetical protein -
C4Q26_RS13040 2779242..2780030 - 789 WP_050586735.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2775909..2776349 440


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11497.33 Da        Isoelectric Point: 9.9159

>T95423 WP_027907232.1 NZ_CP026674:2775072-2775371 [Pseudomonas sp. SWI44]
MTYSLEFDARALKEWQKLGDTVRQQLKKKLASVLLNPRVEANRLHSLPDCYKIKLRSSGYRLVYQVIEQEVVVFVVAVDK
REREQAYLEAAERVVGKTS

Download         Length: 300 bp

>T95423 NZ_CP026674:2775072-2775371 [Pseudomonas sp. SWI44]
ATGACCTATAGCCTTGAGTTCGATGCGCGAGCGCTAAAGGAATGGCAAAAGCTGGGGGATACGGTCCGGCAGCAACTCAA
GAAAAAACTCGCCTCGGTTTTGCTCAATCCGAGGGTTGAGGCGAACCGGCTGCATAGCTTGCCGGACTGCTACAAGATCA
AGCTGCGCAGTAGCGGCTACCGATTGGTCTACCAGGTGATCGAACAAGAGGTTGTAGTTTTTGTGGTAGCTGTGGATAAG
CGCGAGCGGGAACAGGCTTATCTTGAGGCGGCAGAGCGAGTGGTAGGTAAAACGTCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9122.53 Da        Isoelectric Point: 4.6182

>AT95423 WP_023382870.1 NZ_CP026674:2774843-2775082 [Pseudomonas sp. SWI44]
MASINVRIDDDLKIRAYRELERLGVTPSELMRQALQYVAERGQLPFKPVLMTDEDEALLAIVRERLADPQRVRVSLDDL

Download         Length: 240 bp

>AT95423 NZ_CP026674:2774843-2775082 [Pseudomonas sp. SWI44]
ATGGCATCCATCAATGTTCGTATCGACGACGATCTCAAAATCCGAGCCTATCGTGAGCTTGAGCGGTTGGGTGTTACGCC
CTCCGAGCTCATGCGCCAAGCCTTGCAGTACGTCGCCGAGCGCGGGCAGTTGCCTTTTAAGCCTGTGCTCATGACTGATG
AAGATGAGGCGCTGCTAGCGATCGTTCGCGAGCGCCTTGCCGACCCTCAGCGAGTGAGGGTTTCGCTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1HEZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1HF13

References