Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1570059..1570687 Replicon chromosome
Accession NZ_CP026671
Organism Leptospira borgpetersenii serovar Ceylonica strain Piyasena

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C4Q31_RS07665 Protein ID WP_002736113.1
Coordinates 1570059..1570460 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C4Q31_RS07670 Protein ID WP_010705987.1
Coordinates 1570457..1570687 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4Q31_RS07625 1565278..1565508 + 231 WP_002736192.1 hypothetical protein -
C4Q31_RS19095 1565444..1565897 + 454 Protein_1334 hypothetical protein -
C4Q31_RS07635 1565906..1566196 - 291 WP_002736220.1 hypothetical protein -
C4Q31_RS07650 1566989..1567533 - 545 Protein_1336 metal-dependent hydrolase -
C4Q31_RS07655 1567942..1569624 + 1683 WP_002724258.1 dihydroxy-acid dehydratase -
C4Q31_RS07660 1569734..1569913 + 180 WP_002724268.1 hypothetical protein -
C4Q31_RS07665 1570059..1570460 - 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
C4Q31_RS07670 1570457..1570687 - 231 WP_010705987.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C4Q31_RS07675 1570893..1571090 + 198 WP_080595536.1 IS3 family transposase -
C4Q31_RS07685 1572016..1572714 + 699 WP_002724172.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T95420 WP_002736113.1 NZ_CP026671:c1570460-1570059 [Leptospira borgpetersenii serovar Ceylonica]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T95420 NZ_CP026671:c1570460-1570059 [Leptospira borgpetersenii serovar Ceylonica]
ATGACTCAATACTTATTAGATACGAATATTTGCATTTATATAATAAACCAAAAGCCGAGATCTGTTTATAAAAAATTTAA
AAAGATCAAGTTAGAAAACATATTTATTTCATCAATTACGGAATTTGAATTAAAGTATGGTGTTCAAAAAAGTCTTCATC
TCGAAAGGAACTTAAAAATTTTAGAAGAGTTTTTAAGTTATTTGAATATTCTTTCATTTGTTAGTGAAGACGCAAATAAA
GCTGCAAAAATTCGAGTAGAATTAGACAAAGTAGGGAAACCAATCGGTCCTTTCGATCTTTTAATAGCTTCTCAAGCGTT
ATCGAATAAACTTACTCTCGTAACAAACAATGAAAAAGAGTTTACTCGGATCAAAGATATTAAAATTGCAAACTGGCTTT
AA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT95420 WP_010705987.1 NZ_CP026671:c1570687-1570457 [Leptospira borgpetersenii serovar Ceylonica]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT95420 NZ_CP026671:c1570687-1570457 [Leptospira borgpetersenii serovar Ceylonica]
ATGAATAAAGCTAAAATTTTTAAAAATGGGGATAGTCAAGCAATTCGTTTACCGAAAGACTATCGTTTCAAAGGCAAAGA
AGTCTATATACGAAGGGATGGAGATAATGTTATCTTAACGCCAATAAACGATGCGGTTGATCGTTTTTGGAATACGGTTA
ATAGCTTTTCTGACGATCTTATACTTGATCGAAACCAACCAAACGAGTATGGCAAACGAAATAAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References