Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1093674..1094172 Replicon chromosome
Accession NZ_CP026670
Organism Streptococcus pneumoniae strain endophthalmitis isolate 335

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag C4N11_RS05760 Protein ID WP_001809704.1
Coordinates 1093674..1093928 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag C4N11_RS05765 Protein ID WP_000208080.1
Coordinates 1093930..1094172 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4N11_RS05745 1088958..1091426 - 2469 WP_001152992.1 DNA gyrase subunit A -
C4N11_RS05750 1091620..1092606 + 987 WP_000204727.1 L-lactate dehydrogenase -
C4N11_RS05755 1092854..1093627 - 774 WP_000731139.1 ion transporter -
C4N11_RS05760 1093674..1093928 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4N11_RS05765 1093930..1094172 - 243 WP_000208080.1 hypothetical protein Antitoxin
C4N11_RS05770 1094263..1095072 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
C4N11_RS05775 1095074..1096423 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
C4N11_RS05780 1096416..1097120 - 705 WP_000722076.1 response regulator transcription factor -
C4N11_RS05785 1097175..1098350 - 1176 WP_000886152.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T95415 WP_001809704.1 NZ_CP026670:c1093928-1093674 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T95415 NZ_CP026670:c1093928-1093674 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATTGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT95415 WP_000208080.1 NZ_CP026670:c1094172-1093930 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT95415 NZ_CP026670:c1094172-1093930 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References