Detailed information of TA system TA095414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 938259..939496
• Replicon: chromosome
• Accession: NZ_CP026670
• Organism: Streptococcus pneumoniae strain endophthalmitis isolate 335

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: C1CE39
• Locus tag: C4N11_RS05040
• Protein ID: WP_000405356.1
• Coordinates: 938735..939496 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: C4N11_RS05035
• Protein ID: WP_000579605.1
• Coordinates: 938259..938735 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4N11_RS05010	933332..934186	+	855	WP_000900020.1	ADP-ribosylglycohydrolase family protein	-
C4N11_RS05015	934298..935182	+	885	WP_000710119.1	diacylglycerol kinase family lipid kinase	-
C4N11_RS05020	935345..937084	+	1740	WP_000423450.1	glycoside hydrolase family 13 protein	-
C4N11_RS05025	937170..937487	+	318	WP_000995820.1	hypothetical protein	-
C4N11_RS05030	937533..937814	+	282	WP_000266233.1	hypothetical protein	-
C4N11_RS05035	938259..938735	+	477	WP_000579605.1	helix-turn-helix domain-containing protein	Antitoxin
C4N11_RS05040	938735..939496	+	762	WP_000405356.1	zeta toxin family protein	Toxin
C4N11_RS05045	939524..940680	+	1157	Protein_938	hypothetical protein	-
C4N11_RS05055	941512..941871	+	360	WP_000529543.1	hypothetical protein	-
C4N11_RS05060	941881..942210	+	330	WP_000263037.1	MobC family plasmid mobilization relaxosome protein	-
C4N11_RS05065	942233..942850	+	618	WP_000261799.1	relaxase/mobilization nuclease domain-containing protein	-
C4N11_RS05070	942923..943438	+	516	WP_001815879.1	hypothetical protein	-
C4N11_RS05075	943531..944118	+	588	WP_000390752.1	lantibiotic (srt) production protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	923004..950295	27291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29078.11 Da
• Isoelectric Point: 7.1307

>T95414 WP_000405356.1 NZ_CP026670:938735-939496 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELFFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T95414 NZ_CP026670:938735-939496 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTATTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18270.70 Da
• Isoelectric Point: 4.5673

>AT95414 WP_000579605.1 NZ_CP026670:938259-938735 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQHEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGENKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT95414 NZ_CP026670:938259-938735 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACACGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAAATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGCTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTTTCTGATTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4J1TI62