Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1387861..1388453 Replicon chromosome
Accession NZ_CP026656
Organism Aliarcobacter cryaerophilus strain M830MA

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2860_RS07250 Protein ID WP_115588473.1
Coordinates 1387861..1388109 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2860_RS07255 Protein ID WP_148571363.1
Coordinates 1388109..1388453 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2860_RS07230 1383928..1384344 - 417 WP_148571355.1 cyclophilin-like fold protein -
C2860_RS07235 1384354..1385475 - 1122 WP_148571357.1 alpha/beta hydrolase -
C2860_RS07240 1385566..1386468 - 903 WP_236772668.1 AraC family transcriptional regulator -
C2860_RS07245 1386656..1387816 + 1161 WP_148571361.1 MalY/PatB family protein -
C2860_RS07250 1387861..1388109 + 249 WP_115588473.1 type II toxin-antitoxin system HicA family toxin Toxin
C2860_RS07255 1388109..1388453 + 345 WP_148571363.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2860_RS07260 1388544..1389746 - 1203 WP_252970662.1 IS256 family transposase -
C2860_RS07265 1389819..1392824 - 3006 WP_148571883.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-79)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9508.43 Da        Isoelectric Point: 10.4132

>T95399 WP_115588473.1 NZ_CP026656:1387861-1388109 [Aliarcobacter cryaerophilus]
MSKKDKLLLKFLENPPKKDLTFKELNTLLISLGFIKIEGAGSAVKFYNKDKDLLINLHKPHPSDILKVYLIKQIQNKLKE
FL

Download         Length: 249 bp

>T95399 NZ_CP026656:1387861-1388109 [Aliarcobacter cryaerophilus]
ATGAGTAAAAAAGATAAACTTTTATTAAAATTTTTAGAAAATCCACCAAAAAAAGATTTAACTTTTAAAGAGTTAAATAC
ATTATTGATATCTTTAGGGTTTATAAAAATTGAAGGTGCTGGTTCTGCTGTTAAATTTTACAATAAAGATAAAGATTTAT
TAATAAATCTACATAAACCGCATCCAAGTGATATTTTAAAAGTTTATCTTATAAAACAGATACAAAACAAACTTAAGGAG
TTTTTATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12987.76 Da        Isoelectric Point: 4.7253

>AT95399 WP_148571363.1 NZ_CP026656:1388109-1388453 [Aliarcobacter cryaerophilus]
MANIIEYNGYIGTIEYSQEDKCFFGKIDMINDLVTFEAQNANELEENFKNAVDEYILTCKELNREPQKAFKGVFNVRTGS
ELHKLAVLNATKIGVSLNTYIKNLIEKDSKLSLN

Download         Length: 345 bp

>AT95399 NZ_CP026656:1388109-1388453 [Aliarcobacter cryaerophilus]
ATGGCAAATATTATTGAGTATAATGGTTATATAGGAACAATTGAGTATTCACAAGAAGATAAATGTTTTTTCGGAAAAAT
AGATATGATAAATGATTTAGTAACATTTGAAGCACAAAATGCAAATGAATTGGAAGAAAATTTTAAAAATGCAGTTGATG
AGTATATCTTGACTTGTAAAGAGCTAAATAGAGAACCACAAAAAGCATTTAAAGGTGTTTTTAATGTACGAACAGGAAGT
GAACTTCACAAACTTGCAGTTTTAAATGCTACAAAAATAGGTGTTTCTCTAAATACCTATATTAAAAATTTGATAGAAAA
AGATAGTAAATTGTCTTTAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References