Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5712862..5713426 Replicon chromosome
Accession NZ_CP026652
Organism Streptomyces dengpaensis strain XZHG99

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C4B68_RS26495 Protein ID WP_099499306.1
Coordinates 5713079..5713426 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag C4B68_RS26490 Protein ID WP_099499517.1
Coordinates 5712862..5713092 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4B68_RS26475 5708974..5709584 + 611 Protein_5107 3-hydroxyacyl-CoA dehydrogenase -
C4B68_RS26480 5709622..5712201 - 2580 WP_099499308.1 aminopeptidase N -
C4B68_RS26485 5712314..5712802 + 489 WP_099499307.1 DUF1203 domain-containing protein -
C4B68_RS26490 5712862..5713092 + 231 WP_099499517.1 ribbon-helix-helix domain-containing protein Antitoxin
C4B68_RS26495 5713079..5713426 + 348 WP_099499306.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C4B68_RS26500 5713484..5714500 - 1017 WP_099499516.1 aspartate-semialdehyde dehydrogenase -
C4B68_RS26505 5714732..5715271 + 540 WP_180289162.1 sigma-70 family RNA polymerase sigma factor -
C4B68_RS26510 5715273..5716073 + 801 WP_099499304.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12643.75 Da        Isoelectric Point: 10.0392

>T95396 WP_099499306.1 NZ_CP026652:5713079-5713426 [Streptomyces dengpaensis]
MKRGDIYLVDYEPVRGSEASKARPAVIVSNDAANEAVERIGRGVVTLVPLTTNTSRVYPFQVLLPAGEAGLLKDSKVQCE
QVRALALERLLRPIGALPRQRMAEIDLALRRHLAL

Download         Length: 348 bp

>T95396 NZ_CP026652:5713079-5713426 [Streptomyces dengpaensis]
ATGAAGCGCGGTGACATCTACTTGGTCGACTACGAACCGGTGCGCGGCAGTGAGGCCAGCAAAGCGCGGCCGGCGGTGAT
CGTGTCGAACGACGCCGCCAACGAGGCGGTGGAGCGGATCGGGCGAGGCGTGGTCACGCTGGTGCCGCTGACGACGAACA
CGTCGCGCGTCTACCCGTTCCAGGTACTGCTTCCCGCCGGGGAGGCGGGTCTCCTGAAGGACTCCAAGGTGCAGTGCGAG
CAAGTGCGTGCTCTGGCCCTGGAAAGGCTTCTGAGGCCGATCGGTGCGCTCCCGCGACAGCGCATGGCCGAGATCGACCT
GGCGCTGCGACGACACCTGGCGCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8512.20 Da        Isoelectric Point: 3.7108

>AT95396 WP_099499517.1 NZ_CP026652:5712862-5713092 [Streptomyces dengpaensis]
MKISVSLPQEDVSFVDEYAARTDADSRSAVIHAAIELLRQAQLVEEYAEAFAEWDGSEDAEFWDQFSGDGLLDEAR

Download         Length: 231 bp

>AT95396 NZ_CP026652:5712862-5713092 [Streptomyces dengpaensis]
ATGAAGATCAGTGTGAGCCTGCCGCAGGAGGACGTCAGCTTCGTCGACGAGTACGCCGCGCGTACCGATGCCGACTCGCG
GTCGGCCGTGATACACGCCGCTATCGAGCTGTTGCGGCAAGCGCAGCTGGTGGAGGAGTACGCGGAGGCCTTCGCCGAGT
GGGACGGCAGCGAGGACGCGGAGTTCTGGGACCAGTTCTCGGGTGACGGGCTGCTCGATGAAGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References