Detailed information of TA system TA095396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 5712862..5713426
• Replicon: chromosome
• Accession: NZ_CP026652
• Organism: Streptomyces dengpaensis strain XZHG99

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: C4B68_RS26495
• Protein ID: WP_099499306.1
• Coordinates: 5713079..5713426 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: C4B68_RS26490
• Protein ID: WP_099499517.1
• Coordinates: 5712862..5713092 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4B68_RS26475	5708974..5709584	+	611	Protein_5107	3-hydroxyacyl-CoA dehydrogenase	-
C4B68_RS26480	5709622..5712201	-	2580	WP_099499308.1	aminopeptidase N	-
C4B68_RS26485	5712314..5712802	+	489	WP_099499307.1	DUF1203 domain-containing protein	-
C4B68_RS26490	5712862..5713092	+	231	WP_099499517.1	ribbon-helix-helix domain-containing protein	Antitoxin
C4B68_RS26495	5713079..5713426	+	348	WP_099499306.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
C4B68_RS26500	5713484..5714500	-	1017	WP_099499516.1	aspartate-semialdehyde dehydrogenase	-
C4B68_RS26505	5714732..5715271	+	540	WP_180289162.1	sigma-70 family RNA polymerase sigma factor	-
C4B68_RS26510	5715273..5716073	+	801	WP_099499304.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12643.75 Da
• Isoelectric Point: 10.0392

>T95396 WP_099499306.1 NZ_CP026652:5713079-5713426 [Streptomyces dengpaensis]
MKRGDIYLVDYEPVRGSEASKARPAVIVSNDAANEAVERIGRGVVTLVPLTTNTSRVYPFQVLLPAGEAGLLKDSKVQCE
QVRALALERLLRPIGALPRQRMAEIDLALRRHLAL

Nucleotide

• Length: 348 bp

>T95396 NZ_CP026652:5713079-5713426 [Streptomyces dengpaensis]
ATGAAGCGCGGTGACATCTACTTGGTCGACTACGAACCGGTGCGCGGCAGTGAGGCCAGCAAAGCGCGGCCGGCGGTGAT
CGTGTCGAACGACGCCGCCAACGAGGCGGTGGAGCGGATCGGGCGAGGCGTGGTCACGCTGGTGCCGCTGACGACGAACA
CGTCGCGCGTCTACCCGTTCCAGGTACTGCTTCCCGCCGGGGAGGCGGGTCTCCTGAAGGACTCCAAGGTGCAGTGCGAG
CAAGTGCGTGCTCTGGCCCTGGAAAGGCTTCTGAGGCCGATCGGTGCGCTCCCGCGACAGCGCATGGCCGAGATCGACCT
GGCGCTGCGACGACACCTGGCGCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8512.20 Da
• Isoelectric Point: 3.7108

>AT95396 WP_099499517.1 NZ_CP026652:5712862-5713092 [Streptomyces dengpaensis]
MKISVSLPQEDVSFVDEYAARTDADSRSAVIHAAIELLRQAQLVEEYAEAFAEWDGSEDAEFWDQFSGDGLLDEAR

Nucleotide

• Length: 231 bp

>AT95396 NZ_CP026652:5712862-5713092 [Streptomyces dengpaensis]
ATGAAGATCAGTGTGAGCCTGCCGCAGGAGGACGTCAGCTTCGTCGACGAGTACGCCGCGCGTACCGATGCCGACTCGCG
GTCGGCCGTGATACACGCCGCTATCGAGCTGTTGCGGCAAGCGCAGCTGGTGGAGGAGTACGCGGAGGCCTTCGCCGAGT
GGGACGGCAGCGAGGACGCGGAGTTCTGGGACCAGTTCTCGGGTGACGGGCTGCTCGATGAAGCGCGGTGA